内分泌干扰物通过在环境中越来越普遍存在以及与哺乳动物内分泌系统的潜在相互作用，对人类健康构成日益增长的威胁。由于它们与雌激素等激素的结构相似，这些化学物质可能干扰内分泌信号传导，引发许多有害影响。接触雌激素内分泌干扰化合物(EDC)是乳腺癌发展的一种可能风险因素，乳腺癌是女性中最常见的癌症之一。然而，EDC对乳腺癌发展的机制尚不清楚。为了迅速增殖，癌细胞采取特定的代谢程序，利用肿瘤微环境中现有的营养物质并从头合成大分子。已知EDC会破坏与细胞代谢相关的细胞信号通路，这可能是它们发挥促癌作用的一个重要机制。通过代谢组学分析可以研究这些被改变的途径，这是-组学技术的一个新进展，可以调查有利于癌症发展和进展的分子途径。本综述将总结关于EDC及其可能引发的代谢重编程以促进乳腺癌发展的最新发现。 © 2023 The Authors. 出版于Wiley Periodicals LLC的《生化与分子毒理学杂志》

Endocrine-disrupting chemicals pose a growing threat to human health through their increasing presence in the environment and their potential interactions with the mammalian endocrine systems. Due to their structural similarity to hormones like estrogen, these chemicals can interfere with endocrine signaling, leading to many deleterious effects. Exposure to estrogenic endocrine-disrupting compounds (EDC) is a suggested risk factor for the development of breast cancer, one of the most frequently diagnosed cancers in women. However, the mechanisms through which EDCs contribute to breast cancer development remain elusive. To rapidly proliferate, cancer cells undertake distinct metabolic programs to utilize existing nutrients in the tumor microenvironment and synthesize macromolecules de novo. EDCs are known to dysregulate cell signaling pathways related to cellular metabolism, which may be an important mechanism through which they exert their cancer-promoting effects. These altered pathways can be studied via metabolomic analysis, a new advancement in -omics technologies that can interrogate molecular pathways that favor cancer development and progression. This review will summarize recent discoveries regarding EDCs and the metabolic reprogramming that they may induce to facilitate the development of breast cancer.© 2023 The Authors. Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.