转录调控失调是癌症的一个特点，并且可能由改变的增强子景观驱动。基因组组织中的最近研究揭示了多个增强子和启动子可以在空间上聚集形成动态的拓扑组装，被称为启动子-增强子中枢，与基因表达的增强明显相关。在本综述中，我们讨论了最近在多种癌症类型中鉴定的启动子-增强子中枢的结构和复杂性。我们进一步讨论了驱动启动子-增强子中枢失调的潜在机制，并推测了它们在病理生理中的功能作用。了解启动子-增强子中枢在转录调控中的作用可以为针对基因组组织的这些复杂特征提供新的治疗方法的洞察。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Transcriptional dysregulation is a hallmark of cancer and can be driven by altered enhancer landscapes. Recent studies in genome organization have revealed that multiple enhancers and promoters can spatially coalesce to form dynamic topological assemblies, known as promoter-enhancer hubs, which strongly correlate with elevated gene expression. In this review, we discuss the structure and complexity of promoter-enhancer hubs recently identified in multiple cancer types. We further discuss underlying mechanisms driving dysregulation of promoter-enhancer hubs and speculate on their functional role in pathogenesis. Understanding the role of promoter-enhancer hubs in transcriptional dysregulation can provide insight into new therapeutic approaches to target these complex features of genome organization.Copyright © 2023 Elsevier Inc. All rights reserved.