结直肠癌（CRC）是全球第二大导致癌症相关死亡的原因，主要原因是转移性疾病的发展。肝脏是最常受影响的部位。转移级联过程依赖于免疫系统、肿瘤和远端器官之间的复杂相互作用。肿瘤与转移部位之间的交流可以通过肿瘤源性细胞外囊泡（EVs）及其载体介导。在过去的15年中，相关研究呈迅速扩展，对这一过程的机制开始有了一定的了解。其中一个关键方面是在转移部位的微环境重塑，这对于形成前转移微环境和随后的转移沉积至关重要。在评估的研究中，作者使用细胞实验和小鼠模型，研究了肿瘤源性细胞外囊泡及其微RNA内容如何与肝星状细胞（HSCs）相互作用。他们展示了这可能导致微环境重塑和结直肠肝转移的形成，使用了他们的实验模型。在本文中，我们检查了有关肿瘤源性EVs对肿瘤微环境的影响的当前证据，以突出CRC和其他恶性肿瘤未来研究的潜在领域。

Colorectal cancer (CRC) is the 2nd leading cause of cancer-related deaths worldwide, primarily due to the development of metastatic disease. The liver is the most frequently affected site. The metastatic cascade relies on a complex interaction between the immune system, tumor, and distant organs. Communication between the tumor and the metastatic site can be mediated by tumor-derived extracellular vesicles (EVs) and their cargo. The mechanisms underlying this process are starting to be understood through research that has rapidly expanded over the past 15 years. One crucial aspect is the remodeling of the microenvironment at the site of metastasis, which is essential for the formation of a premetastatic niche and the subsequent establishment of metastatic deposits. In the evaluated study, the authors use cellular experiments and a mouse model to investigate how tumour derived extracellular vesicles and their microRNA contents interact with hepatic stellate cells (HSCs). They demonstrate how this may lead to remodelling of the microenvironment and the formation of colorectal liver metastasis using their experimental model. In this mini review, we examine the current evidence surrounding tumour derived EVs and their effect on the tumour microenvironment to highlight potential areas for future research in CRC and other malignancies.