人类胆碱脱氢酶（CHDH）是一种位于线粒体内的跨膜蛋白。CHDH已被证明是一种重要的催化酶，催化胆碱氧化生成甜菜碱，并在线粒体损伤后参与线粒体自噬过程。近年来，越来越多的研究集中在CHDH上，并发现它与各种疾病的发病机制密切相关，包括肿瘤预后。在本文中，我们总结了CHDH基因定位、蛋白结构和基本功能，并讨论了CHDH在代谢性疾病和其他疾病研究中的进展。此外，我们描述了CHDH在不同类型恶性肿瘤进展中的调节作用。此外，CHDH在多种疾病的主要致病机制可能与单核苷酸多态性（SNP）有关。我们期望通过诊断CHDH基因SNP位点，为临床诊断和预后预测疾病提供新的策略和依据。我们的工作评估了CHDH作为与一些代谢性疾病和肿瘤诊断相关的分子标记的可行性，这可能为相关疾病和肿瘤的治疗提供新的靶点。版权所有©2023年李、沈、杨、廉、李、李、黄、沈和刘。

Human choline dehydrogenase (CHDH) is a transmembrane protein located in mitochondria. CHDH has been shown to be one of the important catalytic enzymes that catalyze the oxidation of choline to betaine and is involved in mitochondrial autophagy after mitochondrial damage. In recent years, an increasing number of studies have focused on CHDH and found a close association with the pathogenesis of various diseases, including tumor prognosis. Here we summarized the genomic localization, protein structure and basic functions of CHDH and discuss the progress of CHDH research in metabolic disorders and other diseases. Moreover, we described the regulatory role of CHDH on the progression of different types of malignant tumors. In addition, major pathogenic mechanisms of CHDH in multiple diseases may be associated with single nucleotide polymorphism (SNP). We look forward to providing new strategies and basis for clinical diagnosis and prognosis prediction of diseases by diagnosing SNP loci of CHDH genes. Our work evaluates the feasibility of CHDH as a molecular marker relevant to the diagnosis of some metabolic disorders diseases and tumors, which may provide new targets for the treatment of related diseases and tumors.Copyright © 2023 Li, Shen, Yang, Lian, Li, Li, Huang, Shen and Liu.