鉴于长非编码RNA (lncRNA) 在许多癌症中的功能多样性，它们正在受到特别关注。lncRNA 不仅通过参与各种信号通路发挥着癌基因和肿瘤抑制基因的作用，还是多种癌症的预测标志物，包括急性髓系白血病（AML）。考虑到这一点，我们调查了可能充当介导剂的lncRNA，分别是热休克蛋白和铁死亡之间的两个过程，它们在肿瘤发生中似乎密切相关。使用综合生物信息学方法，我们确定了在AML患者中具有预后价值的四个lncRNA（AL138716.1，AC000120.1，AC004947.1和LINC01547）。有趣的是，其中两个（AC000120.1和LINC01547）已经被报道与AML相关，AC004947.1则被认为具有致癌潜力。特别地，所获得的标志显示高风险患者的生存概率较低，反之亦然。据我们所知，这是第一个可能与AML中的热休克蛋白和铁死亡过程相关的lncRNA预测模型。然而，有必要使用患者样本进行验证。版权所有 © 2023 Ge、Wang、Sharma、Jaehde、Essler、Schmid和Schmidt-Wolf。

Owing to their functional diversity in many cancers, long noncoding RNAs (lncRNAs) are receiving special attention. LncRNAs not only function as oncogenes or tumor suppressors by participating in various signaling pathways but also serve as predictive markers for various types of cancer, including acute myeloid leukemia (AML). Considering this, we investigated lncRNAs that may act as a mediator between two processes, i.e., heat shock proteins and ferroptosis, which appear to be closely related in tumorigenesis. Using a comprehensive bioinformatics approach, we identified four lncRNAs (AL138716.1, AC000120.1, AC004947.1, and LINC01547) with prognostic value in AML patients. Of interest, two of them (AC000120.1 and LINC01547) have already been reported to be AML-related, and AC004947.1 is considered to have oncogenic potential. In particular, the signature obtained showed a lower survival probability with high-risk patients, and vice versa. To our knowledge, this is the first predictive model of lncRNA that may correlate with the processes of heat shock proteins and ferroptosis in AML. Nevertheless, validation using patient samples is warranted.Copyright © 2023 Ge, Wang, Sharma, Jaehde, Essler, Schmid and Schmidt-Wolf.