免疫疗法在实体肿瘤中快速发展，尤其在阻断免疫抑制性检查点和采用T细胞转移以进行免疫调节方面取得了重大突破。许多患者受益于免疫疗法。然而，免疫疗法在整体人群中的应答率相对较低，这取决于肿瘤的特征和个体化患者差异。此外，药物耐药和不良反应的发生在很大程度上限制了免疫疗法的发展。最近，纳米药物传递系统（NDDS）的出现似乎通过将药物载体封装在纳米颗粒中，精确地到达肿瘤部位，并具有高稳定性和生物相容性，延长了药物作用周期并大大降低了毒副作用的发生，从而提高了免疫疗法的疗效。在本文中，我们主要综述了NDDS的优势及其增强实体肿瘤中常规免疫疗法的机制，并总结了基于NDDS的治疗策略的最新进展，为新型肿瘤免疫疗法方案的开发提供了有价值的思路。版权所有 © 2023 张，王，张，何，王，韩和秦。

Immunotherapy has developed rapidly in solid tumors, especially in the areas of blocking inhibitory immune checkpoints and adoptive T-cell transfer for immune regulation. Many patients benefit from immunotherapy. However, the response rate of immunotherapy in the overall population are relatively low, which depends on the characteristics of the tumor and individualized patient differences. Moreover, the occurrence of drug resistance and adverse reactions largely limit the development of immunotherapy. Recently, the emergence of nanodrug delivery systems (NDDS) seems to improve the efficacy of immunotherapy by encapsulating drug carriers in nanoparticles to precisely reach the tumor site with high stability and biocompatibility, prolonging the drug cycle of action and greatly reducing the occurrence of toxic side effects. In this paper, we mainly review the advantages of NDDS and the mechanisms that enhance conventional immunotherapy in solid tumors, and summarize the recent advances in NDDS-based therapeutic strategies, which will provide valuable ideas for the development of novel tumor immunotherapy regimen.Copyright © 2023 Zhang, Wang, Zhang, He, Wang, Han and Qin.