von Willebrand病（VWD）与胃肠道血管畸形有关。这种并发症在VWD 2A型和3型中更为频繁，可能是由于异常血管生成，但具体机制尚不清楚。血管生成和炎症密切相关，可以相互促进。在VWD环境中，癌症手术中的结肠炎是否能促进血管生成？一名患有VWD 3型的女性因腺癌接受了两次部分结肠切除手术。在第一次手术中，采用血浆源性von Willebrand因子（VWF）制剂（Wilfactin; LFB）进行处理后，从肠吻合处的新血管发生顽固性胃肠道出血。经过多学科讨论，采用重组VWF制剂（Veyvondi; 武田制药）进行了第二次手术。在新吻合处再次观察到病理性新生血管。在两个不同的手术中，结肠切除术均出现了两次因病理性新生血管在肠吻合处引起的并发症，其中一次采用了血浆源性VWF制剂，另一次采用了重组VWF制剂。© 2023年Elsevier公司代表国际血栓与止血学会出版。

von Willebrand disease (VWD) is associated with vascular malformations in the gastrointestinal tract. This complication, more frequent in VWD types 2A and 3, may be due to abnormal angiogenesis, but the precise mechanism is still unclear. Angiogenesis and inflammation are closely linked and can potentiate each other.Can colon inflammation in the setting of cancer surgery potentiate angiogenesis in the VWD setting?A woman with VWD type 3 underwent partial colectomy twice for an adenocarcinoma. After managing the first surgery with a plasma-derived von Willebrand factor (VWF) concentrate (Wilfactin; LFB), refractory gastrointestinal bleeding occurred from neovessels on bowel anastomosis. After a multidisciplinary discussion, a second surgery was undertaken with a recombinant VWF concentrate (Veyvondi; Takeda Pharmaceuticals). Pathologic neovessels were again observed on the new anastomosis.Colectomy was complicated twice by pathologic neovessels on bowel anastomosis in 2 distinct procedures managed either with plasma-derived VWF or with recombinant VWF.© 2023 Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.