细胞外信号调节激酶5（ERK5），也被称为BMK1或MAPK7，是经典丝裂原活化蛋白激酶（MAPK）家族的最新成员。该家族包括诸如ERK1/2、c-Jun N末端激酶（JNK）和p38丝裂原活化蛋白激酶（p38 MAPK）等众所周知的成员，以及ERK3、ERK4、ERK7（ERK8）和Nemo-like激酶（NLK）等非典型MAPK。其他综合性综述提供了关于ERK5的详细见解，感兴趣的读者可以参考以获得深入的知识（Nithianandarajah-Jones等人，2012年；Monti等人，《Cancers (Basel)》，2022年，第14期）。本综述的主要目的是强调ERK5的基本特征，并阐明其激活的复杂性质，特别关注其在疾病途径中无需催化的功能。版权所有 © 2023 Le.

Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family. This family includes well-known members such as ERK1/2, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), as well as atypical MAPKs such as ERK3, ERK4, ERK7 (ERK8), and Nemo-like kinase (NLK). Comprehensive reviews available elsewhere provide detailed insights into ERK5, which interested readers can refer to for in-depth knowledge (Nithianandarajah-Jones et al., 2012; Monti et al., Cancers (Basel), 2022, 14). The primary aim of this review is to emphasize the essential characteristics of ERK5 and shed light on the intricate nature of its activation, with particular attention to the catalytic-independent functions in disease pathways.Copyright © 2023 Le.