通过使用双重刺激法，检查对于良好卵巢反应者癌症患者进行卵母细胞检索以进行生育保护的第二次卵巢刺激的最佳时机。本研究采用回顾性分析方法，使用2010年至2021年四家日本机构的69名癌症患者的数据进行卵母细胞检索以进行生育保护。22名患者进行了两次卵母细胞检索以进行生育保护。我们研究了通过双重刺激初次检索的卵母细胞数量与卵巢肿大风险的关系以及第一次卵巢刺激结束和第二次卵巢刺激开始之间的适当等待间隔。当初次通过双重刺激检索的卵母细胞数量≥5时，卵巢肿大的风险较高。8天的等待间隔可能对于在这些情况下进行第二次卵巢刺激卵母细胞检索更有效，尽管差异不显著。本研究提供了一种有效管理卵巢肿大和第二次卵巢刺激的时机的方案，用于对癌症患者进行生育保护卵母细胞检索的双重刺激法。如果更多机构采用这种方法，就能在短期内获得更多用于生育保护的卵母细胞。© 2023 作者。《生殖医学与生物学》由John Wiley & Sons Australia, Ltd代表日本生殖医学学会出版。

To examine the optimal timing of second ovarian stimulation using the dual stimulation method for good ovarian responders with cancer undergoing oocyte retrieval for fertility preservation.A retrospective analysis was conducted using data from 69 patients with cancer who underwent oocyte retrieval for fertility preservation at four Japanese institutions during 2010-2021. Twenty-two patients underwent two oocyte retrievals for fertility preservation. We studied the relationship between the initial number of oocytes retrieved via dual stimulation and risk of ovarian enlargement as well as the appropriate waiting interval between the end of the first ovarian stimulation and beginning of the second ovarian stimulation.The risk of ovarian enlargement was high when the initial number of oocytes retrieved via dual stimulation was ≥5. An 8-day waiting interval may be more effective for performing a second ovarian stimulation oocyte retrieval in these cases, although the difference was not significant.This study provides one policy for effectively managing ovarian enlargement and timing of second ovarian stimulation during oocyte retrieval via the dual stimulation method for patients with cancer undergoing fertility preservation. If more facilities implement this procedure, more oocytes may be obtained in a short period for fertility preservation purposes.© 2023 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.