溶血性贫血和镰状细胞特质患者的炎性标志物水平表达差异明显。
Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait.
发表日期：2023 Aug
作者：
Ingrid Cristiane Pereira Gomes, Lucas Sousa Magalhães, Lays Gisele Santos Bomfim, Priscila Lima Dos Santos, Roberto Jerônimo Dos Santos Silva, Maria Carollyne Passos Cruz, Lindemberg Costa de Albuquerque, Victoria Haydée Deusdedith Neves, Paula Gabriella Pereira Rosa de Oliveira, Alessandro Freire Carvalho, Lucas Oliveira Silva, Matheus Todt Aragão, Tatiana Rodrigues Moura, Rosana Cipolotti
来源：
CYTOKINE & GROWTH FACTOR REVIEWS
摘要：
尽管镰状细胞贫血（SCA）与炎症有关，但有关镰状细胞特征（SCT）中炎症标志物的研究甚少。本研究是一项横断面研究，包括处于稳定状态的SCA成年人、SCT及对照组的炎症生物标志物分析。SCA组的乳酸脱氢酶、IL-1β、IL-6、IL-10和肿瘤坏死因子α水平均高于其他组，而SCT组的水平与对照组相似。此外，SCA组的IL-8/IL-10和可溶性促发炎细胞触发受体1/IL-10比值较低。这些结果表明，SCT患者没有慢性炎症表观，同时加强了细胞因子在SCA炎症状态维持中的作用。© 2023 The Authors. eJHaem出版权由British Society for Haematology和John Wiley & Sons Ltd所有。
Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross-sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL-8/IL-10 and soluble triggering receptor expressed on myeloid cells-1/IL-10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.© 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.