肿瘤微环境（TME）是一个复杂的生态系统，积极参与癌症发生和发展的各个阶段。肿瘤生物行为的一些特征，如增殖、迁移、侵袭、抑制凋亡、免疫逃逸、血管生成和代谢重编程，受到肿瘤微环境的影响。研究表明，非编码RNA，特别是长链非编码RNA和肿瘤源性外泌体中的微小RNA，作为调节血管生成的机制，促进细胞间通讯。它们刺激肿瘤生长、血管生成、转移和肿瘤微环境重编程。通过探索外源性非编码RNA与肿瘤相关内皮细胞之间的关系，以及它们在血管生成中的作用，临床医生将获得新的治疗观点。版权所有 © 2023 Duan、Fu、Jiang、Peng、Ousmane、Zhang和Wang。

The tumor microenvironment (TME) is an intricate ecosystem that is actively involved in various stages of cancer occurrence and development. Some characteristics of tumor biological behavior, such as proliferation, migration, invasion, inhibition of apoptosis, immune escape, angiogenesis, and metabolic reprogramming, are affected by TME. Studies have shown that non-coding RNAs, especially long-chain non-coding RNAs and microRNAs in cancer-derived exosomes, facilitate intercellular communication as a mechanism for regulating angiogenesis. They stimulate tumor growth, as well as angiogenesis, metastasis, and reprogramming of the TME. Exploring the relationship between exogenous non-coding RNAs and tumor-associated endothelial cells, as well as their role in angiogenesis, clinicians will gain new insights into treatment as a result.Copyright © 2023 Duan, Fu, Jiang, Peng, Ousmane, Zhang and Wang.