近年来，在高级皮肤器官陈列方面取得了显著进展。作为能模拟人类皮肤的三维模型，这些器官发展成复杂结构，并且由于能克服二维体系的局限性和伦理顾虑，日益被认为是传统培养模型和人类皮肤的有效替代品。皮肤器官的固有可塑性使其能够构建成生理和病理模型，以实现对皮肤发育和动态变化的研究。本综述概述了从三维分层表皮到具有附属物的囊样皮肤器官的关键研究进展。此外，它还突出了最新的器官构建进展，如三维打印和微流控技术的应用。综述还总结和讨论了皮肤器官在发育生物学、疾病建模、再生医学和个体化医学等方面的多样化应用，同时考虑了其前景和局限。©2023. 人民军医出版社。

Significant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids have evolved into complex structures and are increasingly recognized as effective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional systems and ethical concerns. The inherent plasticity of skin organoids allows for their construction into physiological and pathological models, enabling the study of skin development and dynamic changes. This review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with appendages. Furthermore, it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques, such as 3D printing and microfluidic devices. The review also summarizes and discusses the diverse applications of skin organoids in developmental biology, disease modelling, regenerative medicine, and personalized medicine, while considering their prospects and limitations.© 2023. People´s Military Medical Press.