大蒜（Allium sativum L.）是一种被广泛认可具有药用证据的植物，富含膳食和药物特性，在传统药物中使用已久。它被认为具有良好的抗氧化、抗真菌、抗菌、抗糖尿病、抗炎、抗癌和抗病毒等效果，并具有心血管疾病、抗动脉粥样硬化、降压、抗血栓形成、调节血压、骨骼和皮肤问题等其他治疗作用。目的：考虑到大蒜在心血管/与心脏相关疾病治疗中的潜力，本研究的主要目标是编写以该草药化学和药理学为重点的以患者为中心的小型综述，以期探讨其在心脏相关问题中的应用。为了准备这篇小型综述文章，我们进行了广泛的在线文献搜索，以查找与这个主题相关的最新研究。这些研究被简要回顾、评估和讨论，以探索大蒜在治疗心血管问题方面的可能能力。几项对小鼠模型、大鼠模型和人类进行的实验显示了不同形式的大蒜在心血管或与心脏相关疾病中的有效作用。通过审查与心脏相关问题的大蒜发表的可获得出版物，作者发现硫（S）-有机化合物及其大蒜可能具有在治疗心血管疾病方面的有利应用。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至epub@benthamscience.net。

Allium sativum L. (Garlic) is a well-recognized plant of great nutraceutical value with pharmacological evidences. It is full of dietary as well as pharmaceutical properties and has been used in traditional medications for a long time. It is known for good antioxidant, antifungal, antibacterial, anti-diabetic, anti-inflammatory, anticancer, and antiviral effects, along with other therapeutic roles in cardiovascular diseases, anti-atherosclerotic, antihypertensive, anti-thrombotic, blood pressure, bone and skin related problems etc. Objective: Considering the potential of garlic in the treatment of cardiovascular/heart-related diseases, the main objective of this study was to prepare a subject-centric mini-review focusing on its chemistry and pharmacology in heart-related issues.In order to prepare this mini-review article, an extensive online literature search was performed to find out the most recent studies related to this topic. These studies were briefly reviewed, assessed, and discussed to explore the possible capability of garlic for the cure of cardiovascular problems.Several experiments on mice models, rat models as well as on humans show the effective role of various forms of garlic in cardiovascular or heart-related ailments. After reviewing the available publications on garlic in heart-related issues, authors found that garlic and its sulfur (S)-based organic constituents may have advantageous applications in the treatment of cardiovascular diseases.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.