输卵管是受精和前植入胚胎发育的地点。覆盖输卵管的上皮由多纤毛和分泌细胞组成，这些细胞支持受精和前植入发育，然而，它的稳态机制仍不明确。CD133/Prom1表达已经被用作鉴定各种器官中成体干细胞群体的标记物，并且常与癌干细胞特性相关。通过使用针对CD133的抗体和基于Cre-重组酶的细胞谱系追踪策略，我们发现CD133/Prom1表达与输卵管干/祖细胞群体无关，而主要标记具有低生成能力的多纤毛细胞。此外，我们表明，在新生儿发育过程中，CD133在输卵管中的定位不同，并且Prom1表达的分泌细胞在输卵管囊内迅速转变为多纤毛细胞，并逐渐迁移到上皮褶皱的脊部。©2023 The Company of Biologists Ltd. 由该公司出版。

The oviduct or fallopian tube is the site of fertilization and preimplantation embryonic development. The epithelium lining the oviduct consists of multiciliated and secretory cells, which support fertilization and preimplantation development, however, its homeostasis remains poorly understood. CD133/Prom1 expression has been used as a marker to identify adult stem cell populations in various organs and often associated with cancer stem cell property. Using an antibody targeted to CD133 and a Cre-recombinase based lineage tracing strategy, we find that CD133/Prom1 expression is not associated with a stem/progenitor population in the oviduct but marks predominantly multiciliated cells with a low generative capacity. Additionally, we show that CD133 is disparately localised along the oviduct during neonatal development, and that Prom1 expressing secretory cells in the ampulla rapidly transition to multiciliated cells and progressively migrated to the ridge of epithelial folds.© 2023. Published by The Company of Biologists Ltd.