Myc是在各种组织中驱动肿瘤发生的最为知名的致癌基因之一。从大脑到血液，其失调破坏了细胞正常功能的生理途径。Myc的作用是在基因表达水平上进行的，Myc基本上控制了转录的各个方面。事实上，除了作为一个经典的、与染色质结合的转录因子外，Myc还控制了RNA聚合酶II（RNAPII）的转录暂停释放、延伸和终止以及mRNA的帽子化。因此，明显的是，对Myc功能的最小干扰会导致恶性细胞行为，并且大量的文献主要关注Myc的功能失调。在健康细胞中，Myc控制着与细胞周期（及其增殖）、细胞凋亡、新陈代谢和细胞大小、血管生成、分化和干细胞自我更新等关键功能有关的分子机制。在这个后一方面，研究老化和再生医学领域中一个热门话题的组织再生中，Myc还被发现参与其调节。事实上，Myc似乎在伤口愈合、周围神经、肝脏、胰腺甚至心脏的恢复中起着作用。在这里，我们讨论了Myc在组织再生中的作用的最新研究现状，概述了其除了癌症以外的强大作用。

Myc is one of the most well-known oncogenes driving tumorigenesis in a wide variety of tissues. From the brain to blood, its deregulation derails physiological pathways that grant the correct functioning of the cell. Its action is carried out at the gene expression level, where Myc governs basically every aspect of transcription. Indeed, in addition to its role as a canonical, chromatin-bound transcription factor, Myc rules RNA polymerase II (RNAPII) transcriptional pause-release, elongation and termination and mRNA capping. For this reason, it is evident that minimal perturbations of Myc function mirror malignant cell behavior and, consistently, a large body of literature mainly focuses on Myc malfunctioning. In healthy cells, Myc controls molecular mechanisms involved in pivotal functions, such as cell cycle (and proliferation thereof), apoptosis, metabolism and cell size, angiogenesis, differentiation and stem cell self-renewal. In this latter regard, Myc has been found to also regulate tissue regeneration, a hot topic in the research fields of aging and regenerative medicine. Indeed, Myc appears to have a role in wound healing, in peripheral nerves and in liver, pancreas and even heart recovery. Herein, we discuss the state of the art of Myc's role in tissue regeneration, giving an overview of its potent action beyond cancer.