研究动态
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评估外泌体miRNA作为宫颈癌潜在生物标志物的研究

Evaluation of Exosomal miRNA as Potential Biomarkers in Cervical Cancer.

发表日期:2023 Aug 01
作者: Jéssika Aline do Nascimento Medeiros, Ayane Cristine Alves Sarmento, Emanuelly Bernardes-Oliveira, Ronnier de Oliveira, Maysa Eunice Grigorio Bezerra Lima, Ana Katherine Gonçalves, Deyse de Souza Dantas, Janaina Cristiana de Oliveira Crispim
来源: BIOMEDICINE & PHARMACOTHERAPY

摘要:

不同研究表明,从外泌体中获得的微小非编码RNA,如microRNA (miRNA),被认为是几种癌症,包括宫颈癌 (CC) 的潜在生物标志物。因此,本研究旨在概述循环外泌体miRNA在CC的诊断和预后中作为可能的生物标志物的作用,并根据CC的阶段分析这些miRNA的存在。为此,我们开展了一项综述,收集了2015年至2021年间在MEDLINE/PubMed、Scopus和Web of Science电子数据库中发表的相关文章,并根据符合资格标准的选择研究。根据每篇文章中用于样本分析、检测和分离miRNA的方法,我们还提取了从研究的患者中获得的临床数据,如癌症阶段。在分析这七种miRNA的网络后,发现它们与免疫系统、CC的进展和分期以及顺铂耐药性相关。我们相信,对宫颈癌miRNA的研究将具有重要的临床意义,在本综述中,我们试图总结当前情况和潜在的发展前景。
Different studies show that small non-coding RNAs, such as microRNAs (miRNAs) obtained from exosomes, are considered potential biomarkers in several types of cancer, including cervical cancer (CC). Therefore, the present study seeks to present an overview of the role of circulating exosomal miRNAs with the potential to act as biomarkers for the diagnosis and prognosis of CC and to analyze the presence of these miRNAs according to the stage of CC. For this purpose, a review was developed, with articles consulted from the electronic databases MEDLINE/PubMed, Scopus, and Web of Science published between 2015 and 2021. Seven articles were included after a selection of studies according to the eligibility criteria. In addition to the methods used for sample analysis, detection, and isolation of miRNAs in each article, clinical data were also extracted from the patients studied, such as the stage of cancer. After analyzing the network of the seven miRNAs, they were associated with the immune system, CC progression and staging, and cisplatin resistance. With the belief that studies on miRNAs in cervical cancer would have major clinical implications, in this review, we have attempted to summarize the current situation and potential development prospects.