乳腺癌患者经历一系列与疾病和治疗相关的症状，严重威胁到他们的生活质量。虚拟现实（VR）作为一种新兴的辅助和综合疗法，已在临床实践中越来越多地得到应用。然而，目前缺乏足够的证据支持VR的干预对乳腺癌患者症状管理的有效性。本文旨在系统地研究VR对乳腺癌相关症状管理的效果。在PubMed、EMBASE、Cochrane图书馆、Web of Science、CINAHL、CNKI、万方和维普数据库中全面搜索到2021年4月10日之前发表的随机对照试验（RCTs）和准RCTs。纳入使用基于VR的干预措施来管理乳腺癌相关症状的研究。两名调查员独立地回顾和提取数据，并评估方法学质量。使用RevMan 5.3进行荟萃分析，使用Higgins的I2（%）统计方法评估异质性。最后纳入了8个RCTs和6个准RCTs，共有797名参与者。基于虚拟现实的干预措施显著改善了乳腺癌患者的焦虑、抑郁、疼痛、认知功能和肩关节活动范围等症状，但对握力和上肢功能的改善不显著。基于虚拟现实的干预措施对乳腺癌患者的症状管理具有积极效果。健康专业人员，尤其是护士，可以在临床实践中应用VR，以减轻症状并改善乳腺癌患者的生活质量。需要进行更多研究，希望得出更高质量的结论，并探索VR的最佳干预措施和成本效益。版权所有©2022 Wolters Kluwer Health, Inc. 保留所有权利。

Breast cancer patients experience a range of disease- and treatment-related symptoms that seriously threaten their quality of life. Virtual reality (VR), an emerging complementary and integrative therapy, has been increasingly applied in clinical practice. However, there is insufficient evidence to support the effectiveness of VR-based interventions on symptom management in breast cancer patients.This article aimed to systematically examine the effects of VR on breast cancer-related symptom management.The PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, CNKI, Wan Fang, and VIP databases were comprehensively searched for randomized controlled trials (RCTs) and quasi-RCTs published up to April 10, 2021. Studies using VR-based interventions to manage breast cancer-related symptoms were included. Two investigators independently reviewed and extracted data and evaluated methodological quality. RevMan 5.3 was used for meta-analysis, and heterogeneity was evaluated using Higgins' I2 (%) statistic.Eight RCTs and 6 quasi-RCTs with 797 participants were included. Virtual reality-based interventions significantly improved symptoms of anxiety, depression, pain, cognitive function, and shoulder range of motion in breast cancer patients, but no significant improvements in grip and upper extremity function were observed.Virtual reality-based interventions had a positive effect on symptom management for breast cancer patients.Health professionals, especially nurses, can apply VR in clinical practice to reduce symptoms and improve the quality of life of breast cancer patients. More studies are needed to draw higher quality conclusions and explore the best interventions and cost-effectiveness of VR.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.