神经毒性是乳腺癌（BC）患者化疗的一个主要不良反应。使用一些非药物干预措施来缓解与化疗相关的认知损害（CRCI），然而还没有研究比较了它们的有效性。本研究的目的是确定和比较不同非药物干预措施对BC患者的CRCI的有效性。按照Cochrane的指南进行系统回顾和网络荟萃分析，在Cochrane图书馆，PubMed，MEDLINE（通过OVID），Web of Science，EMBASE和CINAHL数据库中检索所有随机对照试验，时间跨度为从创刊到2021年9月。纳入使用非药物干预措施来管理CRCI症状的研究。使用STATA v14.0进行网络荟萃分析和比较效果排名。纳入了12项涉及8种非药物干预措施的研究。就CRCI的主观结果来说，非药物干预措施之间没有显著差异。就客观结果来说，气功和运动比心理疗法更有效。气功和运动也比音乐疗法更有效。前3种干预措施分别是心理疗法（83.4%），音乐疗法（60.8%）和电针疗法（52.5%）作为主观结果，以及气功（87.7%），运动（82.1%）和电针疗法（70.3%）作为客观结果。在主观评价中，很难判断哪种干预措施最好，但是心理疗法的概率最大。在客观评价中，气功和运动可能是最好的非药物干预措施。本研究为BC患者CRCI的非药物干预措施的有效性提供了证据，并促进了未来临床试验和工作的支持。版权所有©2022 Wolters Kluwer Health, Inc. 保留所有权利。

Neurotoxicity is a major adverse effect of chemotherapy in breast cancer (BC) patients. A number of nonpharmacologic interventions are used to alleviate chemotherapy-related cognitive impairment (CRCI), but no studies have compared their effectiveness.The aim of this study was to identify and compare the effectiveness of different nonpharmacologic interventions for CRCI in BC patients.A systematic review and network meta-analysis was conducted following the Cochrane guidelines. All randomized controlled trials were searched in the Cochrane Library, PubMed, MEDLINE (via OVID), Web of Science, EMBASE, and CINAHL databases from inception to September 2021. Studies using nonpharmacologic interventions to manage CRCI symptoms were included. A network meta-analysis and a comparative effects ranking were completed by STATA v14.0.Twelve studies with 8 nonpharmacologic interventions were included. For subjective outcomes on CRCI, there was no significant difference between nonpharmacologic interventions. For objective outcomes, qigong and exercise were more effective than the psychotherapy. Qigong and exercise were also more effective than music therapy. The top 3 interventions were psychotherapy (83.4%), music therapy (60.8%), and electroacupuncture (52.5%) for subjective outcomes and qigong (87.7%), exercise (82.1%), and electroacupuncture (70.3%) for objective outcomes.In the subjective evaluation, it was difficult to judge which interventions are best, but psychotherapy had the greatest probability. For objective evaluation, qigong and exercise may be the best nonpharmacologic interventions.This study provides evidence for the effectiveness of nonpharmacologic interventions for CRCI in BC patients and facilitates support for future clinical trials and work.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.