原发预防可能是预防癌症的相关策略。鉴于癌症和心血管疾病之间的风险因素和机制的共性，我们研究了中年时期理想心血管健康指标数量与新发癌症之间的关联。在3个欧洲队列研究中（NutriNet-Santé和GAZEL，法国；Whitehall II，英国），在基线时确定了理想心血管健康指标的数量（范围0-7）。癌症事件的随访时间截至2020年10月（NutriNet-Santé），2017年3月（Whitehall II）和2015年12月（GAZEL）。在每个队列中进行Cox回归分析，然后使用随机效应模型合并结果。共有39,718名参与者的数据可用。其中，NutriNet-Santé有16,237人（平均年龄51.3岁；男性占28％），Whitehall II有9418人（平均年龄44.8岁；男性占68％），GAZEL有14,063人（平均年龄45.2岁；男性占75％）。随访的中位数分别为NutriNet-Santé的8.1年，Whitehall II的29.6年，GAZEL的24.8年，共计产生了4889个癌症事件。在每个队列中，理想心血管健康指标数量的增加与整体癌症风险的降低相关，每增加1个理想指标单位的总体危险比（HR）为0.91（95％置信区间[CI]0.88-0.93）。即使移除了吸烟指标，这种关联仍然存在（每增加1个理想指标单位的总体HR为0.94，95％CI为0.90-0.97），并且特定部位的分析表明与肺癌存在显著关联。中年时期理想心血管健康指标的数量增加与较低的癌症风险，特别是肺癌，相关。中年时期原发预防心血管风险因素可能是一种预防癌症发病的补充策略。©2023 CMA Impact Inc.或其许可方。

Primordial prevention may be a relevant strategy for the prevention of cancer. Given the commonality of risk factors and mechanisms between cancer and cardiovascular disease, we examined the associations between the number of ideal cardiovascular health metrics in midlife and incident cancer.In 3 European cohorts (NutriNet-Santé and GAZEL, France; Whitehall II, United Kingdom), the number of ideal cardiovascular health metrics was determined at baseline (range 0-7). Follow-up for cancer events was until October 2020 (NutriNet-Santé), March 2017 (Whitehall II) and December 2015 (GAZEL). Cox regression was conducted in each cohort, and results were thereafter pooled using a random-effects model.Data were available on 39 718 participants. A total of 16 237 were from NutriNet-Santé (mean age 51.3 yr; 28% men), 9418 were from Whitehall II (mean age 44.8 yr; 68% men) and 14 063 were from GAZEL (mean age 45.2 yr; 75% men). The median follow-up was 8.1 years in NutriNet-Santé, 29.6 years in Whitehall II and 24.8 years in GAZEL, and yielded a total of 4889 cancer events. A greater number of ideal cardiovascular health metrics was associated with a lower overall cancer risk in each cohort, with an aggregate hazard ratio (HR) per 1 increment in number of ideal metrics of 0.91 (95% confidence interval [CI] 0.88-0.93). This association remained after removal of the smoking metric (aggregate HR per unit increment in number of ideal metrics: 0.94, 95% CI 0.90-0.97), and site-specific analysis demonstrated a significant association with lung cancer.A greater number of ideal cardiovascular health metrics in midlife was associated with lower cancer risk, notably lung cancer. Primordial prevention of cardiovascular risk factors in midlife may be a complementary strategy to prevent the onset of cancer.© 2023 CMA Impact Inc. or its licensors.