化学趋化因子最初被定义为影响免疫细胞运动的细胞因子。近年来，由于免疫细胞在肿瘤微环境（TME）中的日益重要，化学趋化因子的作用已从单一的“趋化剂”变为可以调节TME并影响肿瘤表型的关键因素。CXCL6，也被称为粒细胞趋化因子-2（GCP-2），可以招募中性粒细胞，在炎症过程中完成非特异性免疫。与癌症相关的基因和白细胞介素家族可以促进CXCL6的异常分泌，从而促进TME中的肿瘤生长、转移、上皮间充质转化和血管生成。CXCL6还在促进纤维化和组织损伤修复方面发挥作用。在本综述中，我们专注于影响CXCL6表达的调控网络，以及基于TME如何影响炎症及肿瘤发生和进展的作用，试图为炎症和癌症等疾病的治疗提供潜在靶点。 © 2023。作者（们）与Springer Nature Switzerland AG签订独家许可协议。

Chemokines were originally defined as cytokines that affect the movement of immune cells. In recent years, due to the increasing importance of immune cells in the tumor microenvironment (TME), the role of chemokines has changed from a single "chemotactic agent" to a key factor that can regulate TME and affect the tumor phenotype. CXCL6, also known as granulocyte chemoattractant protein-2 (GCP-2), can recruit neutrophils to complete non-specific immunity in the process of inflammation. Cancer-related genes and interleukin family can promote the abnormal secretion of CXCL6, which promotes tumor growth, metastasis, epithelial mesenchymal transformation (EMT) and angiogenesis in the TME. CXCL6 also has a role in promoting fibrosis and tissue damage repair. In this review, we focus on the regulatory network affecting CXCL6 expression, its role in the progress of inflammation and how it affects tumorigenesis and progression based on the TME, in an attempt to provide a potential target for the treatment of diseases such as inflammation and cancer.© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.