对于血液恶性肿瘤相关嗜酸性皮肤疾病（EDHM）的发病机制尚不清楚。以前认为是对昆虫叮咬的超敏反应，现在认为免疫失调和细胞因子失衡可能负有责任。它的预后意义尚不明确。本文描述了一系列肿瘤血液患者中EDHM的临床、病理和免疫学发现。一项观察性前瞻性队列研究，涉及2017年4月至2018年12月接受EDHM诊断的肿瘤血液患者。在422例肿瘤血液患者中，鉴定出15例EDHM患者（10名女性和5名男性）。疾病表现从坚实的红斑丘疹到多形性表现不一。病变部位最常见于暴露部位，其中有8例患者回忆起虫叮咬。13例患者报告了病变的季节性。6例患者的IgE水平升高，循环中IL-4和IL-5在正常范围内。15例患者中有12例在化疗后出现皮肤病变。浸润物可以富含嗜酸性粒细胞或淋巴细胞。有趣的是，组织病理学发现与节肢动物叮咬相一致。我们的研究支持了昆虫叮咬在EDHM中的作用。EDHM可能与侵袭性血液病相关。 版权所有 © 2023 Michelerio, Tomasini, Fiandrino, De Amici, Varettoni, Defrancesco, Cavalloni, Brazzelli, Derlino, Paulli, Arcaini and Vassallo.

The pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear.To describe the clinical, pathological and immunological findings in a series of oncohematological patients with EDHM.An observational prospective cohort study of oncohematological patients receiving a diagnosis of EDHM between April 2017 and December 2018.A total of 15 patients with EDHM (10 females and 5 males) were identified among 422 oncohematological patients. Disease presentation varied from firm erythematous papules to more polymorphic presentations. The lesions were most prevalent on the exposed sites, 8/15 patients recalled an insect bite. Lesion seasonality was reported in 13/15 patients. IgE levels were elevated in six patients, circulating IL-4 and IL-5 were within a normal range. Twelve out of 15 patients developed skin manifestations after chemotherapy. The infiltrate could be eosinophil-rich or lymphocytic-rich. Interestingly, the histopathologic findings were in accordance with arthropod bites.A role for insect bites in EDHM is supported by our findings. EDHM may be related to aggressive hematologic disease.Copyright © 2023 Michelerio, Tomasini, Fiandrino, De Amici, Varettoni, Defrancesco, Cavalloni, Brazzelli, Derlino, Paulli, Arcaini and Vassallo.