近期纳米医学的进展引入了一系列在癌症治疗和诊断中使用的智能纳米颗粒。然而，它们在临床应用中仍然面临与生物相容性、消除和生物分布相关的几个挑战。本文中，我们提出了可破裂的有机硅介孔纳米颗粒，即纳米笼，能够高效地装载货物分子，并被不同的脂质组成物涂层以增强其仿生行为。我们利用有机硅表面与脂质混合物相反电荷之间的静电相互作用，以获得高效的有机硅覆盖层。经过涂脂的纳米笼被证明具有极高的血液相容性，与原始纳米笼相比显著增加，并具有良好的胶体稳定性和生物相容性。装载药物且涂脂的纳米笼在体外上对两种不同的癌细胞株进行了测试和比较，证明了脂质涂层在介导纳米笼的内吞作用上起到了关键的作用，通过增强和迅速的细胞摄取进行评估。治疗剂的高效胞内输送通过引入到硅骨架中的二硫键来确保有机硅的破坏，在还原介质中（如胞内介质）被还原为硫醇，从而导致纳米颗粒的破裂。能够成像和有效杀灭癌细胞证明了涂脂的纳米笼作为一种强有力的抗癌研究工具和有前景的智能治疗诊断平台的潜力。

The recent nanomedicine advancements have introduced a variety of smart nanoparticles in cancer treatment and diagnostics. However, their application to the clinic is still hindered by several challenges related to their biocompatibility, elimination and biodistribution. Here we propose breakable organosilica mesoporous nanoparticles, i.e. nanocages, able to efficiently incorporate cargo molecules and be coated, with different lipid compositions, to enhance their biomimetic behaviour. We exploit the electrostatic interactions between the organosilica surface and the opposite charge of the lipid mixtures in order to obtain an efficient organosilica coverage. The lipid-coated nanocages are proved to have an incredibly high hemocompatibility, significantly increased with respect to pristine nanocages, and excellent colloidal stability and biocompatibility. The cargo-loaded and lipid-coated nanocages are tested and compared in vitro on two different cancer cell lines, demonstrating the key role played by the lipid coating in mediating the internalization of the nanocages, evaluated by the enhanced and rapid cellular uptake. The efficient intracellular delivery of the therapeutic agents is then assured by the destruction of the organosilica, due to the disulfide bridges, introduced into the silica framework, that in reducing media, like the intracellular one, are reduced to thiols causing the breaking of the nanoparticles. The possibility to image and effectively kill cancer cells demonstrates the potentiality of the lipid-coated nanocages as a powerful tool in anticancer research and as a promising smart theranostic platform.