将肿瘤免疫环境调控至更为活跃的状态可以提高治疗效果。在这里，我们描述了一种易于获取的细菌生物矿化产生的免疫调节剂，我们将其命名为“Ausome”（Au + [exo]some）。Ausome由金纳米颗粒核心覆盖细菌组分而成；前者提供诱导性高温效应，而后者调动多样化的免疫反应。多种模式识别受体积极参与Ausome引发的免疫反应，导致广谱的促炎细胞因子释放以及效应免疫细胞的激活。当激光照射时，肿瘤中堆积的Ausome引发高温反应，提升组织血流灌注，有助于增强免疫刺激模块的渗透，包括细胞因子和效应淋巴细胞。Ausome介导的这种免疫调控策略最终产生全面的免疫反应，并选择性地增强局部抗肿瘤免疫的效果，在雌性小鼠的临床前癌症模型中增强了已确立的化疗或免疫疗法的疗效。© 2023. Springer Nature Limited.

Manipulating the tumor immune contexture towards a more active state can result in better therapeutic outcomes. Here we describe an easily accessible bacterial biomineralization-generated immunomodulator, which we name Ausome (Au + [exo]some). Ausome comprises a gold nanoparticle core covered by bacterial components; the former affords an inducible hyperthermia effect, while the latter mobilizes diverse immune responses. Multiple pattern recognition receptors actively participate in Ausome-initiated immune responses, which lead to the release of a broad spectrum of pro-inflammatory cytokines and the activation of effector immune cells. Upon laser irradiation, tumor-accumulated Ausome elicits a hyperthermic response, which improves tissue blood perfusion and contributes to enhanced infiltration of immunostimulatory modules, including cytokines and effector lymphocytes. This immune-modulating strategy mediated by Ausome ultimately brings about a comprehensive immune reaction and selectively amplifies the effects of local antitumor immunity, enhancing the efficacy of well-established chemo- or immuno-therapies in preclinical cancer models in female mice.© 2023. Springer Nature Limited.