随着年龄的增长，内在能力（IC），即身体和心理能力的综合，会以不同的速度和模式在个体之间出现下降。本研究旨在调查血浆生物标志物与老年人长期IC轨迹之间的关联，这些生物标志物反映了衰老的两个标志：慢性炎症和线粒体功能受损。我们从多领域阿尔茨海默预防试验（MAPT）中纳入了1271名社区老年人（平均[标准差]年龄=76.0 [4.3]岁），其IC数据覆盖了四年。我们进行了群体多轨迹模型分析，以确定具有相似长期模式的参与者群体，包括四个IC领域：认知、运动、心理和活力。确定了五个IC多轨迹群组：所有领域低（8.4%），运动领域低（24.6%），心理领域低（16.7%），强壮（即除活力外在所有领域中得分较高；28.3%）和具有高活力的强壮（22.0%）。与最佳轨迹群组（具有高活力的强壮）相比，血浆白细胞介素-6（IL-6）、肿瘤坏死因子受体-1（TNFR-1）和生长分化因子-15（GDF-15）的升高水平与属于“所有领域低”群组的风险增加相关（IL-6：相对风险比（RRR）[95%可信区间]= 1.42 [1.07-1.88]；TNFR-1：RRR = 1.46 [1.09-1.96]；GDF-15: RRR = 1.99 [1.45-2.73]）。更高的IL-6和GDF-15也增加了属于“运动领域低”群组的风险。 GDF-15通过与IC轨迹群组的最强关联，优于其他生物标志物。我们的研究结果表明，反映炎症和线粒体损伤的血浆生物标志物可以区分IC轨迹多系统受损的老年人和IC高稳定的老年人。 © 2023作者授权给美国老龄化协会。

Intrinsic capacity (IC), the composite of physical and mental capacities, declines with age at different rates and patterns between individuals. We aimed to investigate the association between longitudinal IC trajectories and plasma biomarkers of two hallmarks of aging-chronic inflammation and mitochondrial dysfunction-in older adults. From the Multidomain Alzheimer Preventive Trial (MAPT), we included 1271 community-dwelling older people (mean [SD] age = 76.0 [4.3] years) with IC data over four years. Group-based multi-trajectory modeling was performed to identify clusters of the participants with similar longitudinal patterns across four IC domains: cognition, locomotion, psychology, and vitality. Five IC multi-trajectory groups were determined: low in all domains (8.4%), low locomotion (24.6%), low psychological domain (16.7%), robust (i.e., high in all domains except vitality; 28.3%), and robust with high vitality (22.0%). Compared to the best trajectory group (i.e., robust with high vitality), elevated levels of plasma interleukin-6 (IL-6), tumor necrosis factor receptor-1 (TNFR-1), and growth differentiation factor-15 (GDF-15) were associated with a higher risk of belonging to the "low in all domains" group (IL-6: relative risk ratio (RRR) [95% CI] = 1.42 [1.07 - 1.88]; TNFR-1: RRR = 1.46 [1.09 - 1.96]; GDF-15: RRR = 1.99 [1.45 - 2.73]). Higher IL-6 and GDF-15 also increased the risk of being in the "low locomotion" group. GDF-15 outperformed other biomarkers by showing the strongest associations with IC trajectory groups. Our findings found that plasma biomarkers reflecting inflammation and mitochondrial impairment distinguished older people with multi-impaired IC trajectories from those with high-stable IC.© 2023. The Author(s), under exclusive licence to American Aging Association.