目标在日常临床实践中，卵巢病变的鉴别诊断是一个重要问题，超声波似乎是最有效的诊断技术。我们的研究旨在外部评估不同诊断模型在不同经验水平的检查者应用时的性能。方法这是一项诊断准确度研究，包括2018年7月至2021年4月间入院接受附件肿块治疗的女性，来自希腊的一家三级肿瘤中心。术前的超声数据由一位专家妇科医生、一名六年级和一名一年级妇科住院医师进行评估，他们应用了国际卵巢肿瘤分析(IOTA)简单规则(SR)和卵巢肿瘤的不同评估模型(ADNEX)来鉴别良性和恶性卵巢肿瘤。术后病理报告被用作参考诊断。我们使用Kappa统计量来调查被检查系统和评分人之间的一致性水平。结果我们纳入了66名女性，其中39名患有良性卵巢肿瘤，27名患有恶性卵巢肿瘤。当由所有评分人员应用时，ADNEX(带和不带"CA-125")具有很高的敏感性(96%-100%)，但在一年级住院医师应用时，其特异性较低(36%)。SR在6%至17%的病例中无法应用。与ADNEX相比，SR具有稍低的敏感性、较高的特异性和较高的总体准确度，尤其是在一年级住院医师应用时(61% vs. 92%)。结论在不具备肿瘤学中心条件的情况下，ADNEX和SR都可以用于筛查，因为它们在经验较少的检查者使用时具有很高的敏感性。对于经验不足的检查者来说，SR似乎是评估卵巢病变的最佳模型。作者：这是一篇由Thieme出版的开放获取文章，根据创作共用署名-非衍生-非商业许可协议发表，允许复制和再制作，前提是原作品得到适当的证书。内容不得用于商业用途，也不得进行改编、混合、变换或建立在此之上。(https://creativecommons.org/licenses/by-nc-nd/4.0/)。

Objectives The discrimination of ovarian lesions presents a significant problem in everyday clinical practice with ultrasonography appearing to be the most effective diagnostic technique. The aim of our study was to externally evaluate the performance of different diagnostic models when applied by examiners with various levels of experience. Methods This was a diagnostic accuracy study including women who were admitted for adnexal masses, between July 2018 and April 2021, to a Greek tertiary oncology center. Preoperatively sonographic data were evaluated by an expert gynecologist, a 6 th and a 1 st year gynecology resident, who applied the International Ovarian Tumor Analysis (IOTA) Simple Rules (SR) and Assessment of Different NEoplasias in the adneXa (ADNEX) model to discriminate between benign and malignant ovarian tumors. The explant pathology report was used as the reference diagnosis. Kappa statistics were used for the investigation of the level of agreement between the examined systems and the raters. Results We included 66 women, 39 with benign and 27 with malignant ovarian tumors. ADNEX (with and without "CA-125") had high sensitivity (96-100%) when applied by all raters but a rather low specificity (36%) when applied by the 1st year resident. SR could not be applied in 6% to 17% of the cases. It had slightly lower sensitivity, higher specificity, and higher overall accuracy, especially when applied by the 1st year resident (61% vs. 92%), compared to ADNEX. Conclusion Both ADNEX and SR can be utilized for screening in non-oncology centers since they offer high sensitivity even when used by less experienced examiners. In the hands of inexperienced examiners, SR appears to be the best model for assessing ovarian lesions.The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).