细胞介导的主要免疫应答在癌症发展和进展中起着重要作用。除了免疫细胞和肿瘤细胞之间的相互作用外，还存在其他免疫相关细胞和结构对抗肿瘤的关键因素。其中，淋巴细胞结构和B淋巴细胞作为治疗癌症的有力策略备受关注。现有证据表明淋巴细胞结构在调节肿瘤微环境中的免疫反应中具有重要作用，尤其是B淋巴细胞。通过影响免疫细胞的活化状态、激活免疫细胞、抑制肿瘤细胞的生长和扩散等多种机制，B淋巴细胞能够有效抵抗癌症的发展。因此，深入研究淋巴细胞结构和B淋巴细胞的作用机制，发展相关的治疗策略，对于癌症治疗具有重要意义。
Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer.
发表日期：2023
作者：
Laura Esparcia-Pinedo, Nuria Romero-Laorden, Arantzazu Alfranca
来源：
CYTOKINE & GROWTH FACTOR REVIEWS
摘要：
Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that resembles that of secondary lymphoid organs. Both structures share common developmental characteristics, although TLSs usually appear in chronically inflamed non-lymphoid tissues, such as tumors. TLSs contain diverse types of immune cells, with varying degrees of spatial organization that represent different stages of maturation. These structures support both humoral and cellular immune responses, thus the correlation between the existence of TLS and clinical outcomes in cancer patients has been extensively studied. The finding that TLSs are associated with better prognosis in some types of cancer has led to the design of therapeutic strategies based on promoting the formation of these structures. Agents such as chemokines, cytokines, antibodies and cancer vaccines have been used in combination with traditional antitumor treatments to enhance TLS generation, with good results. The induction of TLS formation therefore represents a novel and promising avenue for the treatment of a number of tumor types. 特等淋巴结构(TLS)是淋巴细胞的聚集体，其组织结构类似于二级淋巴器官。尽管两种结构具有共同的发育特征，但TLS通常出现在慢性炎症非淋巴组织，如肿瘤。TLS含有多种类型的免疫细胞，具有不同程度的空间组织，代表不同的成熟阶段。这些结构支持体液和细胞免疫应答，因此TLS存在与癌症患者临床结果的相关性已得到广泛研究。在某些癌症类型中，发现TLS与更好的预后相关，从而导致设计基于促进这些结构形成的治疗策略。化学因子、细胞因子、抗体以及癌症疫苗等药物与传统抗肿瘤治疗联合使用以增强TLS生成，取得良好效果。因此，诱导TLS形成代表着治疗多种肿瘤类型的一条新颖和有前途的途径。 版权所有© 2023 Esparcia-Pinedo, Romero-Laorden和Alfranca
Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that resembles that of secondary lymphoid organs. Both structures share common developmental characteristics, although TLSs usually appear in chronically inflamed non-lymphoid tissues, such as tumors. TLSs contain diverse types of immune cells, with varying degrees of spatial organization that represent different stages of maturation. These structures support both humoral and cellular immune responses, thus the correlation between the existence of TLS and clinical outcomes in cancer patients has been extensively studied. The finding that TLSs are associated with better prognosis in some types of cancer has led to the design of therapeutic strategies based on promoting the formation of these structures. Agents such as chemokines, cytokines, antibodies and cancer vaccines have been used in combination with traditional antitumor treatments to enhance TLS generation, with good results. The induction of TLS formation therefore represents a novel and promising avenue for the treatment of a number of tumor types.Copyright © 2023 Esparcia-Pinedo, Romero-Laorden and Alfranca.