平均寿命的增加导致了老龄人口的增长，从而导致了神经退行性疾病的普遍存在，如帕金森病（PD）。PD是第二常见的神经退行性疾病，其特征是黑质致密部多巴胺能神经元的进行性退化。海洋环境已被证明是一种具有巨大治疗潜力的独特和多样化的化学结构来源，可用于治疗多种病理状况，包括神经退行性障碍。本综述重点关注从海洋生物中分离出的具有神经保护作用的化合物，以其化学结构、分类学、神经保护效果以及它们在PD中的可能作用机制为基础，采用体外和体内模型进行评估。报道了来自海洋细菌、真菌、软体动物、海参、海藻、软珊瑚、海绵和海星等具有PD治疗潜力的约60种化合物。这些化合物包括肽、生物碱、醌类、萜类物质、多糖、多酚类、脂质、色素和真菌毒素。它们可以在几个PD特征中发挥作用，减少氧化应激、预防线粒体功能障碍、α-突触核蛋白聚集，并通过抑制NF-kB因子的转位、降低人类肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6）的水平来阻断炎症通路。本综述总结了表现出作用于PD发展相关细胞内信号通路的靶点的海洋天然产物，这些产物应作为未来临床前研究的考虑对象。

The increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson's disease (PD). PD is the second most common neurodegenerative disorder and is characterized by a progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). The marine environment has proven to be a source of unique and diverse chemical structures with great therapeutic potential to be used in the treatment of several pathologies, including neurodegenerative impairments. This review is focused on compounds isolated from marine organisms with neuroprotective activities on in vitro and in vivo models based on their chemical structures, taxonomy, neuroprotective effects, and their possible mechanism of action in PD. About 60 compounds isolated from marine bacteria, fungi, mollusk, sea cucumber, seaweed, soft coral, sponge, and starfish with neuroprotective potential on PD therapy are reported. Peptides, alkaloids, quinones, terpenes, polysaccharides, polyphenols, lipids, pigments, and mycotoxins were isolated from those marine organisms. They can act in several PD hallmarks, reducing oxidative stress, preventing mitochondrial dysfunction, α-synuclein aggregation, and blocking inflammatory pathways through the inhibition translocation of NF-kB factor, reduction of human tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6). This review gathers the marine natural products that have shown pharmacological activities acting on targets belonging to different intracellular signaling pathways related to PD development, which should be considered for future pre-clinical studies.