研究动态
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新的骨WB-SPECT/CT:从头到脚的混合,数字化! 这值得努力吗?

The new bone WB-SPECT/CT: hybrid, from head-to-toe and digital! Is it worth the effort?

发表日期:2023 Aug 25
作者: Luca Filippi, Viviana Frantellizzi, Giuseppe De Vincentis, Orazio Schillaci
来源: Bone & Joint Journal

摘要:

骨显像扫描(BS)在许多肿瘤学和非肿瘤性疾病中起着关键作用。平面BS具有高灵敏度但低特异性的特点。在平面成像方面,单光子发射计算机断层扫描(SPECT)的应用使图像对比度增加,示踪剂定位更准确。本文讨论了骨显像扫描领域中的最新技术创新,特别关注能够覆盖整个扫描长度的多视场设备(WB-SPECT/CT)。此外,还讨论了能将伽马光子直接转换为电脉冲的镉锌碲/CzT探测器的应用(即“数字SPECT”)。 初步临床经验表明,相比“老式”的BS(平面图像带或不带单视场SPECT),WB-SPECT/CT具有更高的灵敏度、诊断准确性和图像解释的信心。此外,由于其更高的灵敏度,基于CzT的探测器可能有助于实施快速采集方案。需要进一步的研究来更好地定义骨CzT WB-SPECT/CT对患者管理和预后的临床影响,以及其成本效益比。
A bone scan (BS) plays a pivotal role in many oncological and non-oncological conditions. Planar BS is characterized by high sensitivity but low specificity. With respect to planar imaging, the implementation of single-photon emission computed tomography (SPECT) has allowed increased image contrast and more accurate tracer localization.Recent technological innovations in the field of BS are treated, with a particular focus on multi-field-of-view devices allowing to cover the entire scan length with a 3D acquisition (WB-SPECT/CT). In addition, the applications of cadmium zinc telluride/CzT detectors capable of converting gamma photons directly into electrical impulses (i.e. 'digital SPECT') are discussed.Initial clinical experiences indicate that WB-SPECT/CT is characterized by higher sensitivity, diagnostic accuracy, and increased confidence in image interpretation with respect to the 'old-fashioned' BS (planar images with or without single field-of-view SPECT). Furthermore, CzT-based detectors, thanks to their superior sensitivity, might be helpful to implement fast acquisition protocols. Further studies are needed to better define the clinical impact of bone CzT WB-SPECT/CT on patients' management and outcome, as well as its cost-benefit ratio.