随着结构化报告越来越多地用于评估前列腺特异性膜抗原正电子发射计算机断层扫描/计算机断层扫描（PSMA-PET/CT）用于前列腺癌的影像，有必要评估这些框架的可靠性。本研究旨在评估使用PSMA-RADS 1.0进行解读PSMA-PET/CT扫描的具有不同经验水平的读者之间的读者内和读者间一致性，并确定即使在无临床数据的情况下，实施该报告系统在临床实践中的可行性。 103名患者的PSMA-PET/CT扫描图像由4名具有不同经验水平的读者根据PSMA-PET/CT成像的报告和数据系统（RADS）进行独立评估，即PSMA-RADS 1.0， 在6周内的2个时点进行评估。对于每个扫描，最多选择五个目标病灶，并根据PSMA-RADS 1.0进行分层。评估总体扫描评分和基于区域的评分。应用内类相关系数（ICC）确定读者内和读者间的一致性。PSMA-RADS 1.0在四个读者之间在总体扫描评分（ICC≥0.91）和基于区域的评分（ICC≥0.93）方面显示出良好的读者间一致性。该框架在总体扫描评分（ICC≥0.86）和基于区域的评分（ICC≥0.95）方面显示出优秀的读者内一致性，即使是在具有不同经验水平的读者中也是如此。PSMA-RADS 1.0是一种可靠的评估PSMA-PET/CT的方法，读者之间具有较强的一致性和一致性。它显示出在诊断和制定治疗前列腺癌患者方面建立标准方法的巨大潜力，即使是对于经验较少的读者也可以有信心使用。该研究强调了PSMA-RADS 1.0是一种有价值且极其可靠的评分系统，用于前列腺癌患者的PSMA-PET/CT扫描，即使在临床常规实践中，也可以由具有不同经验水平的放射科医生放心使用。PSMA-RADS 1.0是一种用于PSMA-PET/CT扫描的评分系统。为了使其适用于临床实践，需要分析其再现性。使用PSMA-RADS 1.0进行总体扫描评分和基于区域的评分，具有不同经验水平的读者之间看到了出色的读者间和读者内一致性。PSMA-RADS 1.0是一个可靠的工具，可用于准确诊断和制定前列腺癌患者的治疗方案，并可以放心地用于临床常规实践。© 2023年，作者。

As structured reporting is increasingly used in the evaluation of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT) for prostate cancer, there is a need to assess the reliability of these frameworks. This study aimed to evaluate the intra- and interreader agreement among readers with varying levels of experience using PSMA-RADS 1.0 for interpreting PSMA-PET/CT scans, even when blinded to clinical data, and therefore to determine the feasibility of implementing this reporting system in clinical practice.PSMA-PET/CT scans of 103 patients were independently evaluated by 4 readers with different levels of experience according to the reporting and data system (RADS) for PSMA-PET/CT imaging PSMA-RADS 1.0 at 2 time points within 6 weeks. For each scan, a maximum of five target lesions were freely chosen and stratified according to PSMA-RADS 1.0. Overall scan score and compartment-based scores were assessed. Intra- and interreader agreement was determined using the intraclass correlation coefficient (ICC).PSMA-RADS 1.0 demonstrated excellent interreader agreement for both overall scan scores (ICC ≥ 0.91) and compartment-based scores (ICC ≥ 0.93) across all four readers. The framework showed excellent intrareader agreement for overall scan scores (ICC ≥ 0.86) and compartment-based scores (ICC ≥ 0.95), even among readers with varying levels of experience.PSMA-RADS 1.0 is a reliable method for assessing PSMA-PET/CT with strong consistency and agreement among readers. It shows great potential for establishing a standard approach to diagnosing and planning treatment for prostate cancer patients, and can be used confidently even by readers with less experience.This study underlines that PSMA-RADS 1.0 is a valuable and highly reliable scoring system for PSMA-PET/CT scans of prostate cancer patients and can be used confidently by radiologists with different levels of experience in routine clinical practice.PSMA-RADS version 1.0 is a scoring system for PSMA-PET/CT scans. Its reproducibility needs to be analyzed in order to make it applicable to clinical practice. Excellent interreader and intrareader agreement for overall scan scores and compartment-based scores using PSMA-RADS 1.0 were seen in readers with varying levels of experience. PSMA-RADS 1.0 is a reliable tool for accurately diagnosing and planning treatment for prostate cancer patients, and can be used confidently in clinical routine.© 2023. The Author(s).