结直肠癌（CRC）是导致癌症相关死亡的主要原因之一。虽然治疗方面取得了进展，但药物耐药性仍然是一个重要的障碍。翻译后修饰（PTMs）调控蛋白稳定性、定位和活性，影响重要的细胞生物过程。最近的研究突出了PTMs在CRC耐药性发展中的重要作用。本综述总结了最新的研究进展，重点关注PTMs在CRC耐药性中的作用。我们讨论了PTMs对CRC耐药性中的信号通路和分子的功能影响，药物开发的进展以及潜在的治疗靶点。我们还总结了PTMs的主要富集方法。最后，我们讨论了当前面临的挑战和未来的发展方向，包括对PTM分析方法和PTM靶向治疗的更全面需求。本综述确定了治疗CRC药物耐药性的潜在干预措施，提出了前瞻性的治疗选择，并概述了PTMs在CRC耐药性中的功能。版权所有©2023 Elsevier B.V. 发表。

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Despite advances in treatment, drug resistance remains a critical impediment. Post-translational modifications (PTMs) regulate protein stability, localization, and activity, impacting vital cellular processes. Recent research has highlighted the essential role of PTMs in the development of CRC resistance. This review summarizes recent advancements in understanding PTMs' roles in CRC resistance, focusing on the latest discoveries. We discuss the functional impact of PTMs on signaling pathways and molecules involved in CRC resistance, progress in drug development, and potential therapeutic targets. We also summarize the primary enrichment methods for PTMs. Finally, we discuss current challenges and future directions, including the need for more comprehensive PTM analysis methods and PTM-targeted therapies. This review identifies potential therapeutic interventions for addressing medication resistance in CRC, proposes prospective therapeutic options, and gives an overview of the function of PTMs in CRC resistance.Copyright © 2023. Published by Elsevier B.V.