蛋白质稳态、细胞健康的重要方面，涵盖蛋白质的合成、折叠和降解的平衡，与人体多种疾病有关。多个相互连接的途径协同维持细胞内的蛋白质稳态。近期，蛋白质稳态网络在肿瘤发生与发展中的作用逐渐浮出水面。本文总结了蛋白质质量控制机制（HSR、UPS、自噬、UPR和ERAD）在肿瘤发展和癌症免疫中的参与情况。此外，还概述了蛋白质质量控制机制和靶向药物的证据，并讨论了将这些药物与癌症免疫疗法结合的尝试。总之，联合治疗代表了未来研究的一个有前景的方向，而这一令人兴奋的见解将通过开发能够在干扰蛋白质稳态的益处与风险之间取得平衡的药物进一步阐明。版权所有 © 2023，由Elsevier B.V.出版。

Protein homeostasis, an important aspect of cellular fitness that encompasses the balance of production, folding and degradation of proteins, has been linked to several diseases of the human body. Multiple interconnected pathways coordinate to maintain protein homeostasis within the cell. Recently, the role of the protein homeostasis network in tumorigenesis and tumour progression has gradually come to light. Here, we summarize the involvement of the most prominent components of the protein quality control mechanisms (HSR, UPS, autophagy, UPR and ERAD) in tumour development and cancer immunity. In addition, evidence for protein quality control mechanisms and targeted drugs is outlined, and attempts to combine these drugs with cancer immunotherapy are discussed. Altogether, combination therapy represents a promising direction for future investigations, and this exciting insight will be further illuminated by the development of drugs that can reach a balance between the benefits and hazards associated with protein homeostasis interference.Copyright © 2023. Published by Elsevier B.V.