尿道膀胱癌（UBC）是影响泌尿系统的最常见的恶性肿瘤。本研究旨在探讨将尿沉渣中的DAPK甲基化与B超声联合应用于复发性UBC检测的诊断价值。本研究纳入了1021例接受尿道膀胱肿瘤电灼术的初发UBC患者，并进行了随访。进行了包括B超声、尿液中DAPK甲基化、尿液脱落细胞检测和膀胱镜检查在内的多种参数检测。采用Kappa检验分析所收集的数据，并构建受试者工作特征曲线（ROC曲线）评估其在回归性UBC中的诊断作用。在这1021例患者中，有115例患者在两年内经膀胱镜和活检确认复发，被排除出研究，有效样本量为906例初发UBC患者。膀胱镜检查结果与B超声（Kappa=0.785，P<0.05）以及与尿沉渣DAPK甲基化呈一致，并且B超声与DAPK甲基化的联合检测（Kappa=0.517，P<0.05，Kappa=0.593，P<0.05）也一致。B超声与DAPK甲基化的联合检测的曲线下面积为0.922，其灵敏度为92.86%，特异性为91.63%，阴性预测值为99.4%，表明阴性结果表示复发的风险较低。尿沉渣中的DAPK甲基化与B超声的联合应用在复发性UBC的诊断中表现出较高的诊断性能。©2023年BioMed Central公司，Springer Nature部分所有。 Note: The company name "BioMed Central Ltd." has been kept as it is and only the year has been translated.

Urinary bladder cancer (UBC) is the most common malignancy affecting the urinary system. This study aimed to investigate the diagnostic value of combining DAPK methylation in urinary sediment and B ultrasound in the detection of recurrent UBC.A total of 1021 cases with primary UBC who underwent electrocision of bladder tumor through urethra were included in this study and followed up. Various parameters including B ultrasound, DAPK methylation in urinary sediment, examination of exfoliated cells in the urine, and cystoscopy were performed. The data collected was analyzed using the Kappa test, and receiver operating characteristic (ROC) curve was constructed to assess the diagnostic role in recurrent UBC.Among the 1021 patients, 115 patients experienced recurrence confirmed by cystoscopy and biopsy within two years and were excluded from the study, resulting in an effective sample size of 906 primary UBC cases. The results of cystoscopy showed agreement with B ultrasound (Kappa = 0.785, P < 0.05), as well as with DAPK methylation in urinary sediment, and the combination of B ultrasound and DAPK methylation (Kappa = 0.517, P < 0.05, Kappa = 0.593, P < 0.05). The combination of B ultrasound with DAPK methylation yielded an area under the curve of 0.922, with a sensitivity of 92.86%, specificity of 91.63%, and a negative predictive value of 99.4%, suggesting that a negative result indicates a low risk of recurrence.The combination of DAPK methylation in urinary sediment with B ultrasound demonstrates high diagnostic performance for recurrent UBC.© 2023. BioMed Central Ltd., part of Springer Nature.