大黄酮类化合物—异黄酮，具有多种生物活性，在各种疾病中得到了广泛研究。在癌症方面，异黄酮表现出一系列的生物效应，如抑制细胞生长、诱导程序性细胞死亡、减少新血管的形成、保护细胞免受氧化应激的损害以及抑制细胞迁移。此外，异黄酮还能增强化疗的疗效。异黄酮的抗癌特性可以归因于多种分子和信号通路，包括血管内皮生长因子（VEGF）、丝裂原活化蛋白激酶（MAPK）、核因子κB（NF-κB）、PI3K/Akt/mTOR和Nrf2/HO-1。因此，异黄酮在抗癌治疗中具有很大的潜力。本综述主要关注异黄酮在抗癌治疗中的生物学功能和各种分子靶点。© 2023. BioMed Central Ltd., part of Springer Nature.

Fisetin, a natural flavonoid, possesses numerous biological activities that have been extensively studied in various diseases. When it comes to cancer, fisetin exhibits a range of biological effects, such as suppressing cell growth, triggering programmed cell death, reducing the formation of new blood vessels, protecting against oxidative stress, and inhibiting cell migration. Moreover, fisetin has the ability to enhance the effectiveness of chemotherapy. The anticancer properties of fisetin can be attributed to a diverse array of molecules and signaling pathways, including vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), PI3K/Akt/mTOR, and Nrf2/HO-1. Consequently, fisetin holds promise as a therapeutic agent for anticancer treatment. In this review, we place emphasis on the biological functions and various molecular targets of fisetin in anticancer therapy.© 2023. BioMed Central Ltd., part of Springer Nature.