胰腺癌（PC）是癌症相关死亡的第七大原因。PC发病率每年都在男性和女性中持续增加约1%。尽管PC的5年相对生存率从3%增加到12%，但在所有癌症中仍然是最低的。因此，迫切需要新的治疗策略。PC靶向治疗策略面临的挑战来自PC高度异质性以及癌细胞与周围微环境之间相互作用的理解不足。促使PC细胞生长的信号通路一直受到密切关注，而坏死程序化细胞死亡的一种独特类型——坏死凋亡也引起了兴趣。在这篇综述中，我们提供坏死凋亡的历史背景，并对坏死凋亡在PC恶性进展中的作用进行详细分析，并讨论了当前关于此问题的辩论。

Pancreatic cancer (PC) is the seventh leading cause of cancer-related death. PC incidence has continued to increase by about 1% each year in both men and women. Although the 5-year relative survival rate of PC has increased from 3% to 12%, it is still the lowest among cancers. Hence, novel therapeutic strategies are urgently needed. Challenges in PC-targeted therapeutic strategies stem from the high PC heterogeneity and from the poorly understood interplay between cancer cells and the surrounding microenvironment. Signaling pathways that drive PC cell growth have been the subject of intense scrutiny and interest has been attracted by necroptosis, a distinct type of programmed cell death. In this review, we provide a historical background on necroptosis and a detailed analysis of the ongoing debate on the role of necroptosis in PC malignant progression.