水果和蔬菜不仅在营养方面有用，还被用作用于治疗各种疾病和病症的药物。这些食品是植物化学物质的重要来源，这些化学物质对多种疾病具有抗癌预防和治疗作用。毛浣花碱（HSN）是一种天然存在于不同的钩藤物种中的吲哚生物碱，具有多种治疗益处。它存在于食物中，如鱼、海鲜、肉类、禽类、乳制品和一些谷物制品等。此外，它还存在于水果和蔬菜中，包括玉米、菜花、蘑菇、土豆、笋、香蕉、哈密瓜和柑橘类水果。本研究的主要目的是总结HSN对不同疾病的药理活性和潜在机制，以及生物药学特征。为此，我们通过在PubMed、Springer Link、Scopus、Wiley Online、Web of Science、ScienceDirect和Google Scholar等各种可靠和真实的文献数据库中搜索，收集了数据（截至2023年7月1日）。研究结果表明，HSN在各种临床前和药理实验系统中产生多种效应。它表现出抗炎、抗病毒、抗糖尿病和抗氧化活性，在神经系统和心血管疾病中具有益处。我们的研究结果还表明，HSN通过多种分子机制（包括凋亡性细胞死亡、诱导氧化应激、细胞毒性作用、抑制细胞增殖、基因毒性作用以及抑制癌细胞迁移和侵袭）对多种癌症（如肺癌、乳腺癌和人类T-细胞白血病）表现出有希望的抗癌潜能。总之，本研究的结果表明，HSN可能是一种有希望的治疗剂，可用于治疗包括癌症在内的多种疾病。

Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases and ailments. These food items are prominent sources of phytochemicals that exhibit chemopreventive and therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in various Uncaria species and has a multitude of therapeutic benefits. It is found in foodstuffs such as fish, seafood, meat, poultry, dairy, and some grain products among other things. In addition, it is present in fruits and vegetables including corn, cauliflower, mushrooms, potatoes, bamboo shoots, bananas, cantaloupe, and citrus fruits. The primary emphasis of this study is to summarize the pharmacological activities and the underlying mechanisms of HSN against different diseases, as well as the biopharmaceutical features. For this, data were collected (up to date as of 1 July 2023) from various reliable and authentic literature by searching different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. Findings indicated that HSN exerts several effects in various preclinical and pharmacological experimental systems. It exhibits anti-inflammatory, antiviral, anti-diabetic, and antioxidant activities with beneficial effects in neurological and cardiovascular diseases. Our findings also indicate that HSN exerts promising anticancer potentials via several molecular mechanisms, including apoptotic cell death, induction of oxidative stress, cytotoxic effect, anti-proliferative effect, genotoxic effect, and inhibition of cancer cell migration and invasion against various cancers such as lung, breast, and antitumor effects in human T-cell leukemia. Taken all together, findings from this study show that HSN can be a promising therapeutic agent to treat various diseases including cancer.