本研究旨在合成以壳聚糖/聚乙烯醇（CS/PVA）为基础的氧化锌（ZnO）和二氧化钛（TiO2）混合生物纳米复合材料（BNCs），并观察其对皮肤癌细胞系A431和抗氧化潜力的比较表现。将CS与PVA混合以形成聚合物薄膜，分别增强ZnO和TiO2纳米颗粒（NPs）的固定化。通过物化研究（如含水率、润湿性和接触角测量）优化了BNCs的性能。观察了BNCs对1,1-二苯基-2-苦基肼的自由基清除活性，并且抗大肠杆菌菌株的抑制区域较大。此外，通过不同浓度（50、100、150、200和300 μg/mL）的抗癌活性研究揭示了合成的BNCs对皮肤癌细胞株A431的抗癌作用。抗癌研究显示，与TiO2 BNCs相比，在剂量依赖性方面，ZnO BNCs具有高百分比（70%）的癌细胞抑制能力，而TiO2 BNCs具有（61%）的抑制能力。

This study aimed to synthesize chitosan/polyvinyl alcohol (CS/PVA)-based zinc oxide (ZnO) and titanium dioxide (TiO2) hybrid bionanocomposites (BNCs) and observe their comparative accomplishment against the skin cancer cell line, A431, and antioxidant potential. CS was blended with PVA to form polymeric films reinforced with the immobilization of ZnO and TiO2 nanoparticles (NPs), separately. The optimization of the BNCs was done via physicochemical studies, viz. moisture content, swelling ratio, and contact angle measurements. The free radical scavenging activity was observed for 1,1-diphenyl-2-picryl-hydrazyl, and the antibacterial assay against the Escherichia coli strain showed a higher zone of inhibition. Furthermore, the anticancer activity of the synthesized BNCs was revealed against the skin cancer cell line A431 under varying concentrations of 50, 100, 150, 200, and 300 μg/mL. The anticancer study revealed a high percent of cancerous cell inhibition (70%) in ZnO BNCs as compared to (61%) TiO2 BNCs in a dose-dependent manner.