疫苗相关不良反应（VAAEs），包括猫注射部位肉瘤（FISSs），虽然罕见，但可能是严重的。了解潜在的VAAEs是疫苗接种需要告知主人的重要组成部分。在本次综述中，欧洲猫病咨询委员会（ABCD），一个独立的猫科医学专家委员会，通过总结文献并填补缺少科学研究的专家意见，为兽医采用最佳疫苗接种实践提供当前猫科VAAEs的相关知识。VAAEs由异常的先天或适应性免疫反应、接种部位的过度局部反应、接种错误或制造过程中的故障引起。FISS是最严重的VAAE，可能在接种或注射其他物质后发展。虽然最被广泛接受的假设是慢性炎症引发了恶性转化，但FISS的发病机制尚未完全理解。没有注射疫苗是完全无风险的，因此，接种疫苗应该尽可能频繁地进行，但尽可能地少次数。疫苗在接种前应该先回到室温，并注射在FISS手术可能能够治愈的部位；应避免在肩胛间区域注射。注射后的监测是必不可少的。

Vaccine-associated adverse events (VAAEs), including feline injection-site sarcomas (FISSs), occur only rarely but can be severe. Understanding potential VAAEs is an important part of informed owner consent for vaccination. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of feline medicine experts, presents the current knowledge on VAAEs in cats, summarizing the literature and filling the gaps where scientific studies are missing with expert opinion to assist veterinarians in adopting the best vaccination practice. VAAEs are caused by an aberrant innate or adaptive immune reaction, excessive local reactions at the inoculation site, an error in administration, or failure in the manufacturing process. FISS, the most severe VAAE, can develop after vaccinations or injection of other substances. Although the most widely accepted hypothesis is that chronic inflammation triggers malignant transformation, the pathogenesis of FISS is not yet fully understood. No injectable vaccine is risk-free, and therefore, vaccination should be performed as often as necessary, but as infrequently as possible. Vaccines should be brought to room temperature prior to administration and injected at sites in which FISS surgery would likely be curative; the interscapular region should be avoided. Post-vaccinal monitoring is essential.