在血液肿瘤患者、重症住院患者和重症监护室（ICU）患者中，侵袭性真菌感染（IFIs）导致明显的发病率和死亡率。我们在非洲对这些风险群体中的IFIs进行了世界卫生组织推荐的基本诊断测试的调查。全球真菌感染行动（GAFFI）评估了非洲人群对IFIs的诊断测试的不同获得水平，旨在构建比较数据集和可公开使用的交互地图。通过向与相关主题（例如HIV、实验室协调）的国家领导人和/或卫生部代表进行验证的问卷调查和2轮的视频电话验证以及后续确认电子邮件来收集数据。初步数据从涵盖99.65％的非洲人口的48个国家收集。在超过一半的设施中，通常使用血液培养、直接显微镜检查和组织病理学检查来诊断IFIs。支气管镜检查在20个国家中很少进行或根本不进行（人口6.49亿）。在40多个非洲国家（人口>8.5亿）中，没有在公共或私人部门中进行阿斯佩异双歧杆菌抗原检测。计算机断层扫描（CT）成像在27个（56％）公共部门的国家和21个（44％）私人部门的国家中常规使用。但在大多数非洲国家，核磁共振成像相对不常见。非洲缺乏IFIs基本诊断测试的可用性，尤其是阿斯佩异双歧杆菌抗原检测和现代医学成像技术。早期诊断和针对性治疗IFIs对于复杂癌症治疗的最佳结果至关重要。版权所有©2023年作者。由Elsevier Ltd.出版。保留所有权利。

Invasive fungal infections (IFIs) contribute to significant morbidity and mortality among patients with haemato-oncological conditions, seriously ill hospitalised patients and those in intensive care (ICU). We surveyed for the World Health Organization-recommended essential diagnostic tests for IFIs in these risk groups in Africa.The Global Action For Fungal Infections (GAFFI) evaluated the different levels of access to both diagnostics for IFIs for populations in Africa, with the aim of building a comparative dataset and a publicly available interactive map. Data was collected through a validated questionnaire administered to a country leader in relevant topics (i.e., HIV, laboratory coordination) and/or Ministry of Health representatives and followed up with 2 rounds of validation by video calls, and later confirmation by email of findings.Initial data was collected from 48 African countries covering 99.65 % of the population. Conventional diagnostics such as blood cultures, direct microscopy and histopathology were often used for diagnosis of IFIs in more than half of the facilities. Bronchoscopy was rarely done or not done in 20 countries (population 649 million). In over 40 African countries (population >850 million), Aspergillus antigen testing was never performed in either the public or private sectors. Computed tomography (CT) imaging is routinely used in 27 (56 %) of countries in the public sector and 21 44 %) in the private sector. However, magnetic resonance imaging remains relatively uncommon in most African countries.There are critical gaps in the availability of essential diagnostics for IFIs in Africa, particularly Aspergillus antigen testing and modern medical imaging modalities. Early diagnosis and commencement of targeted therapy of IFIs are critical for optimal outcomes from complex cancer therapies.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.