本研究旨在评估切除后胆囊腺癌患者循环肿瘤细胞（CTCs）的预后影响。2018年1月至2021年1月，纳入了101例连续的胆囊腺癌患者。使用CanPatrol®技术检测和计数CTCs。随访期截至2023年1月。采用对数秩和Cox回归分析计算癌症特异性生存（CSS）和无病生存（DFS）率。 在未手术组中，61.54％（8/13）患者CTCs检测呈阳性，而手术组中为13.64％（12/88）。在手术组中，CTCs阳性和CTCs阴性患者的中位CSS分别为5.0个月和9.5个月（P < 0.001），DFS分别为2.8个月和5.0个月（P < 0.001）。在未手术组中，CTCs阳性和CTCs阴性患者的中位CSS分别为3.5个月和6.5个月（P = 0.0031）。手术组CTCs阳性患者的中位CSS与未手术组类似（P = 0.67）。多因素分析显示，阳性CTCs是胆囊腺癌患者CSS不良预后的独立危险因素（HR 0.066，95％CI 0.021-0.206，P < 0.001），与淋巴浸润（HR 0.320，95％CI 0.110-0.930，P = 0.036），缺乏R0根治性切除（HR 7.520，95％CI 2.100-26.931，P = 0.002），以及缺乏辅助化疗（HR 7.730，95％CI 2.416-24.731，P < 0.001）相关。阳性CTCs是胆囊腺癌切除后预后不良的独立预测因子。术前检测CTCs可能在制定这些患者的治疗策略方面发挥重要的指导作用。 ©2023年。外科肿瘤学会。

The study aimed to evaluate the prognostic impact of circulating tumor cells (CTCs) in patients with gallbladder adenocarcinoma after resection.Between January 2018 and January 2021, 101 consecutive patients with gallbladder adenocarcinoma were included. CTCs were detected and enumerated using the CanPatrol® technique. The follow-up period ended in January 2023. The cancer-specific survival (CSS) and disease-free survival (DFS) were calculated using log-rank and Cox regression analyses.CTCs were detected positively in 61.54% (8/13) of the patients in the non-operation group and 13.64% (12/88) in the operation group. In the operation group, the median CSS for CTCs-positive and CTCs-negative patients was 5.0 and 9.5 months (P < 0.001), respectively, and DFS was 2.8 and 5.0 months at stage III (P < 0.001), respectively. In the non-operation group, the median CSS for CTCs-positive and CTCs-negative patients was 3.5 and 6.5 months (P = 0.0031), respectively. The median CSS for CTCs-positive patients in the operation group was similar to that in the non-operation group (P = 0.67). Multivariate analyses showed that positive CTCs was an independent risk factor for poor CSS (HR 0.066, 95% CI 0.021-0.206, P < 0.001) as well as lymph infiltration (HR 0.320, 95% CI 0.110-0.930, P = 0.036), without R0 curative resection (HR 7.520, 95% CI 2.100-26.931, P = 0.002), and without adjuvant chemotherapy (HR 7.730, 95% CI 2.416-24.731, P < 0.001).Positive CTCs was an independent predictor of poor prognosis after resection in patients with gallbladder adenocarcinoma. Preoperative detection of CTCs may play an important guiding role in formulating treatment strategies for these patients.© 2023. Society of Surgical Oncology.