为了确定在子宫内膜癌手术后围手术期和生存期患者中2型糖尿病（T2DM）诊断的患病率，进行了IRB批准的回顾性单机构队列研究，研究对象是2014年至2020年期间接受子宫内膜癌手术管理的患者。围手术期被定义为手术前后30天。记录了生存期间T2DM的诊断。T2DM的诊断标准是HgbA1c≥6.5%或随机血糖≥200mg/dL。通过单因素分析研究了围手术期T2DM的后果和未来T2DM的预测因素。 符合纳入标准的519名患者中，37名（7.1%）在围手术期被诊断出患有T2DM。与无T2DM的患者相比，围手术期被诊断为T2DM的患者的BMI显著增高（p = 0.006），但年龄（p = 0.20）、种族/人种（p > 0.05）或ECOG评分（p = 0.19）没有显著差异。除了血管并发症（p = 0.005）外，两组之间的术中并发症率没有显著差异，围手术期T2DM组的术后任何并发症发生率较高（p = 0.01）。在随访时间中位数29个月[范围11.6-49.0个月]内，该队列中有额外的18.3%（n = 88）患者符合T2DM的诊断标准。BMI（p < 0.001）、围手术期血糖（p < 0.001）和HgbA1c（p = 0.002）是在生存期间诊断T2DM的风险因素。 在这个子宫内膜癌患者的回顾性队列研究中，25.4%的患者被诊断为T2DM，其中大多数在生存期间被诊断。子宫内膜癌的手术管理和随后的监测为诊断有风险的T2DM患者提供了机会。版权所有© 2023 Elsevier Inc.。保留所有权利。

To determine the prevalence of Type 2 diabetes mellitus (T2DM) diagnoses during the peri-operative and survivorship periods in patients following surgical management of endometrial cancer (EC).An IRB-approved, retrospective single-institution cohort study was performed in patients who underwent surgical management of EC from 2014 to 2020. The perioperative period was defined as the 30 days before and after surgery. T2DM diagnoses occurring during survivorship were recorded. T2DM diagnoses were defined by a HgbA1c ≥6.5% or a random blood glucose ≥200 mg/dL. Sequelae of peri-operative T2DM and predictors of future T2DM were examined utilizing univariate analysis.Of 519 patients meeting inclusion criteria, 37 (7.1%) were diagnosed with T2DM in the perioperative period. Patients diagnosed with T2DM in the perioperative period had significantly higher BMI (p = 0.006) compared to no T2DM, but there were no significant differences in age (p = 0.20), ethnicity/race (p > 0.05) or ECOG score (p = 0.19). The rates of intraoperative complications between groups did not significantly differ, except for vascular complications (p = 0.005), and the incidence of any postoperative complication was higher in the perioperative T2DM group (p = 0.01). With a median follow-up of 29 months [range 11.6-49.0 months], an additional 18.3% (n = 88) of the cohort met diagnostic criteria for T2DM. BMI (p < 0.001), perioperative glucose (p < 0.001), and HgbA1c (p = 0.002) demonstrate risk for a T2DM diagnosis during survivorship.In this retrospective cohort of EC patients, 25.4% were diagnosed with T2DM, with the majority diagnosed in the survivorship period. Surgical management and subsequent surveillance of EC presents an opportunity to diagnose at-risk patients with T2DM.Copyright © 2023 Elsevier Inc. All rights reserved.