RB介导的E2F调控是一个高度保守的细胞周期机制的组成部分。然而，RB的肿瘤抑制活性，如在动物发育中对RB的需求，是组织特异性的、上下文特定的，有时看起来与细胞增殖脱钩。RB基因组分布的详细新信息为RB功能的复杂性提供了新的视角，暗示其功能特异性的一部分来源于特定上下文中RB与染色质的关联。本文总结了最近的证据，显示RB在不同细胞周期阶段靶向不同类型的染色质调控元件。RB在S期之前控制传统的RB/E2F靶点，但当细胞增殖时，RB重新分布到细胞类型特异的染色质位点。我们讨论了新数据对RB研究的广泛影响。版权所有© 2023作者。由Elsevier出版有限公司发表。保留所有权利。

The retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with chromatin. Here we summarize recent evidence showing that RB targets different types of chromatin regulatory elements at different cell cycle stages. RB controls traditional RB/E2F targets prior to S-phase, but, when cells proliferate, RB redistributes to cell type-specific chromatin loci. We discuss the broad implications of the new data for RB research.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.