基于碳水化合物聚合物的表面修饰纳米递送系统近年来受到了很大关注，用于增强对结直肠癌的定向递送。这些系统利用了碳水化合物聚合物的独特性质，如生物相容性、生物可降解性和控释性。这些性质使它们成为药物递送应用的适当候选者。已有丰富研究对装载生物活性化合物的纳米递送系统进行用于定向结直肠癌递送的研究。然而，这些药物的靶向效果在各种纳米递送系统中仍然受限。为了克服这一限制，纳米颗粒的表面修饰以碳水化合物聚合物如壳聚糖、果胶、藻酸盐和瓜尔豆胶等，展示了增强靶向能力以及增强抗癌效果。最近，构建了一种以鞣酸和维生素E为基础的壳聚糖装饰的PLGA纳米颗粒，显示出具有长期释放特定靶点的能力以及更高的抗癌效果。类似地，壳聚糖结合葡萄糖醛酸包被的二氧化硅纳米颗粒装载了卡培他滨，研究发现其具有pH响应性的控释特性，以及更高的抗癌效果。表面修饰的碳水化合物聚合物在改善结直肠癌的靶向递送方面具有极大潜力。通过利用这些聚合物的独特性质，如表面修饰、pH响应性、黏附性、药物控释和联合治疗，在研究人员的努力下，已经在结直肠癌的治疗策略中取得了更加有效和有针对性的治疗方法。 版权所有 © 2023. Elsevier B.V.出版。

Carbohydrate polymers-based surface-modified nano-delivery systems have gained significant attention in recent years for enhancing targeted delivery to colon cancer. These systems leverage carbohydrate polymers' unique properties, such as biocompatibility, biodegradability, and controlled release. These properties make them suitable candidates for drug delivery applications. Nano-delivery systems loaded with bioactive compounds are well-studied for targeted colorectal cancer delivery. However, those drugs' target reach is still limited in various nano-delivery systems. To overcome this limitation, surface modification of nanoparticles with carbohydrate polymers like chitosan, pectin, alginate, and guar gum showed enhanced target-reaching capacity along with enhanced anticancer efficacy. Recently, a chitosan-decorated PLGA nanoparticle was constructed with tannic acid and vitamin E and showed long-term release of specific targets along with higher anticancer efficacy. Similarly, Chitosan-conjugated glucuronic acid-coated silica nanoparticles loaded with capecitabine were studied against colon cancer and found to be the pH-responsive controlled release of capecitabine with higher anticancer efficacy. Surface-modified carbohydrate polymers have promising potential for improving colon cancer target delivery. By leveraging the unique properties of these polymers, such as surface modification, pH responsiveness, mucoadhesion, controlled drug release, and combination therapy, researchers are working toward developing more effective and targeted treatment strategies for colon cancer.Copyright © 2023. Published by Elsevier B.V.