我们的研究旨在评估L1细胞粘附分子（L1CAM）在早期宫颈鳞状细胞癌中作为预后因素的表达。这项回顾性、单中心的研究纳入了2007年至2017年之间接受根治性子宫切除术治疗早期鳞状细胞宫颈癌的154名患者。154例患者的肿瘤标本可用于进行L1CAM的免疫组织化学分析。在所有患者中，144例进行了根治性腹腔子宫切除术。整个研究组中，24个肿瘤（15.6%）显示L1CAM的阳性表达。与分化程度和淋巴血管浸润的存在相关，L1CAM表达未显示出关联（p=0.154和p=0.306，分别） 。无病间期和总生存期在L1CAM阳性和L1CAM阴性病例之间也没有显著差异（p=0.427和p=0.240，分别）。对于组织病理学特征，L1CAM阳性病例的肿瘤大小中位数显著较高（p=0.015）。即使在无淋巴结浸润的选定组内的115例病例中，L1CAM状态对随访期间的复发率没有影响。我们的研究未能证实先前的研究结果，即L1CAM表达是宫颈癌的一种负面预后因素。在我们的研究中，早期鳞状细胞宫颈癌中L1CAM的表达增加与疾病复发、无病生存和总生存无明显相关。L1CAM的表达仅与肿瘤大小相关。版权所有© 2023，国际抗癌研究所（George J. Delinasios博士），保留所有权利。

Our study aimed to assess expression of L1 cell adhesion molecule (L1CAM) in early-stage cervical squamous-cell cancer as a prognostic factor.This retrospective, single-institution study included 154 patients who underwent radical hysterectomy for early-stage squamous cell cervical cancer between 2007 and 2017. Tumor samples from 154 patients were available for L1CAM analysis by immunohistochemistry. Among all patients, radical abdominal hysterectomy was performed in 144 cases.L1CAM expression was positive in 24 tumors (15.6%) of the whole group. In relation to the grade of differentiation and the presence of lymphovascular invasion, L1CAM expression did not show an association (p=0.154 and p=0.306, respectively). The disease-free interval and overall survival also did not significantly differ between L1CAM-positive and L1CAM-negative cases (p=0.427 and p=0.240, respectively). For histopathological characteristics, L1CAM-positive cases had a significantly higher median tumor size (p=0.015). Even in the selected group of 115 cases without nodal infiltration, L1CAM status had no effect on the relapse rate during follow-up.Our study did not confirm the results of previous studies showing L1CAM expression to be a negative prognostic factor in cervical cancer. In our study, increased L1CAM expression in early-stage squamous-cell cervical cancer was not associated with adverse prognosis regarding disease recurrence, disease-free survival, nor overall survival. L1CAM expression was correlated only with the size of the tumor.Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.