PI3K信号通路作为一种针对胶质母细胞瘤的分子靶点。
PI3K signaling pathways as a molecular target for Glioblastoma Multiforme.
发表日期：2023 Aug 30
作者：
Andressa Letícia Lopes da Silva, Thiago Pina Goes de Araújo, Shakira Cavalcante de Albuquerque Ferreira, Anderson Brandão Leite, João Kaycke Sarmento da Silva, Lilyana Waleska Nunes Albuquerque, Ana Rachel Vasconcelos de Lima, Herbert Charles Silva Barros, Leandro Rocha Silva, Edeildo Ferreira da Silva-Júnior, João Xavier de Araújo-Júnior, Vivaldo Moura Neto, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira
来源：
BIOMEDICINE & PHARMACOTHERAPY
摘要：
胶质母细胞瘤（GBM）是影响中枢神经系统（CNS）最常见的癌症类型。目前全球诊断恶性肿瘤中，GBM约占2％，每年报告296,000例新病例。首选治疗方案包括手术切除、放射疗法和辅助化疗，可使患者的生存期增加15个月。新的临床和临床前研究旨在通过寻找能有效消除癌细胞的新药物，绕过治疗抵抗等问题，改善该病预后。治疗GBM的有希望的一个治疗策略是抑制磷脂酰肌醇3-激酶（PI3K）途径，该途径与肿瘤发生相关。本综述旨在讨论针对GBM的PI3K途径特异性治疗共引领的合成或天然药物原型的主要科学研究。版权所有© Bentham Science Publishers；如有任何问题，请发送电子邮件至epub@benthamscience.net。
Glioblastoma multiforme (GBM) is the most common type of cancer that affects the central nervous system (CNS). It currently accounts for about 2% of diagnosed malignant tumors worldwide, with 296,000 new cases reported per year. The first-choice treatment consists of surgical resection, radiotherapy, and adjuvant chemotherapy, which increases patients' survival by 15 months. New clinical and pre-clinical research aims to improve this prognosis by proposing the search for new drugs that effectively eliminate cancer cells, circumventing problems such as resistance to treatment. One of the promising therapeutic strategies in the treatment of GBM is the inhibition of the phosphatidylinositol 3-kinase (PI3K) pathway, which is closely related to the process of tumor carcinogenesis. This review sought to address the main scientific studies of synthetic or natural drug prototypes that target specific therapy co-directed via the PI3K pathway, against human glioblastoma.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.