研究动态
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子宫颈癌的调强放射治疗(IMRT)以减少毒性并提高疗效——选择还是必须?:一个叙述性综述。

Intensity-Modulated Radiation Therapy (IMRT) for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy - an Option or a Must?: A Narrative Review.

发表日期:2023 Aug 30
作者: Sea-Won Lee, Aeran Kim, Sung Jong Lee, Sung Hwan Kim, Jong Hoon Lee
来源: BIOMEDICINE & PHARMACOTHERAPY

摘要:

放射治疗(RT)是宫颈癌治疗中的基本方法。随着技术的不断进步,传统的外部透射线治疗(EBRT)已经快速被调强放射治疗(IMRT)所取代,尤其是在过去十年中。这种更新的技术能够在同一个区域内区分射线的强度,从而减少了射线对正常器官的不可避免的暴露,并且能够更好地向肿瘤输送剂量。最近,美国放射肿瘤学协会发布了一份关于宫颈癌放射治疗的指南。尽管该指南的一部分建议使用IMRT来减少毒副作用,但有必要对文献进行全面回顾以了解IMRT在宫颈癌治疗中的当前状况。这篇综述通过更新最新的高水平证据,介绍了IMRT在宫颈癌治疗中的疗效和毒副作用,并提供了对IMRT实现的最新创新技术在EBRT中的更好了解。
Radiotherapy (RT) is a fundamental modality in treatment of cervical cancer. With advancement of technology, conventional RT used for external beam radiotherapy (EBRT) for over half a century has been rapidly replaced with intensity-modulated radiation therapy (IMRT) especially during the last decade. This newer technique is able to differentiate the intensity of radiation within the same field, thus reduces the inevitable exposure of radiation to normal organs and enables better dose delivery to tumors. Recently, the American Society for Radiation Oncology has released a guideline for RT in cervical cancer. Although a section of the guideline recommends IMRT for the purpose of toxicity reduction, a thorough review of the literature is necessary to understand the current status of IMRT in cervical cancer. This narrative review updates the recent high-level evidences regarding the efficacy and toxicity of IMRT and provides a better understanding of the most innovative techniques currently available for EBRT enabled by IMRT.