囊泡运输是一种不间断且复杂的细胞过程，用于物质运输和信息传递。最近的研究确定了小GTP酶脑系列相关蛋白11A（RAB11A）作为这一过程的关键调节因子。异常的RAB11A表达已被报告在多种癌症类型中，这表明RAB11A在癌症中的重要功能和特征。这些发现非常重要，因为基于RAB11A的生理和病理状态的治疗策略可能使癌症治疗更有效，因为癌症发展的分子机制尚未完全揭示。然而，对于RAB11A的这些研究尚未进行详细审查和讨论。因此，我们总结并讨论RAB11A参与不同生物过程的最新发现，包括内吞回收调节、受体和黏附分子回收、外泌体分泌、吞噬体形成和细胞分裂，以及在几种肿瘤类型中的调节机制。此外，在不同类型的癌症中也观察到RAB11A的对立作用，暗示了RAB11A在癌症中的双重特性，即致癌或抑瘤。对于RAB11A功能和特征的这一综述凸显了基于囊泡运输而诱导多个重要表型的RAB11A的价值，因此将为未来研究揭示RAB11A在不同癌症中的分子机制、临床意义和治疗靶点提供深入见解。版权所有©2023 Elsevier B.V.发行。

Vesicle trafficking is an unceasing and elaborate cellular process that functions in material transport and information delivery. Recent studies have identified the small GTPase, Ras-related protein in brain 11A (RAB11A), as a key regulator in this process. Aberrant RAB11A expression has been reported in several types of cancers, suggesting the important functions and characteristics of RAB11A in cancer. These discoveries are of great significance because therapeutic strategies based on the physiological and pathological status of RAB11A might make cancer treatment more effective, as the molecular mechanisms of cancer development have not been completely revealed. However, these studies on RAB11A have not been reviewed and discussed specifically. Therefore, we summarize and discuss the recent findings of RAB11A involvement in different biological processes, including endocytic recycling regulation, receptors and adhesion molecules recycling, exosome secretion, phagophore formation and cytokinesis, as well as regulatory mechanisms in several tumor types. Moreover, contradictory effects of RAB11A have also been observed in different types of cancers, implying the dual characteristics of RAB11A in cancer, which are either oncogenic or tumor-suppressive. This review on the functions and characteristics of RAB11A highlights the value of RAB11A in inducing multiple important phenotypes based on vesicle trafficking and therefore will offer insights for future studies to reveal the molecular mechanisms, clinical significance, and therapeutic targeting of RAB11A in different cancers.Copyright © 2023. Published by Elsevier B.V.