Nα-乙酰转移酶10蛋白（Naa10p）被认为是N-端乙酰转移酶A（NatA）复合物的催化亚单位，与Naa15p结合以乙酰化人类蛋白质组的N-末端。最近的研究揭示了Naa10p的额外功能，包括赖氨酸ε-乙酰化和非乙酰转移酶相关活性。它的多功能角色已被认为与多种生理和病理情境有关。新出现的证据表明，在癌症进展中，Naa10p在癌基因或肿瘤抑制基因中具有双重属性，取决于肿瘤类型和乙酰转移酶活性背景。在本综述中，我们提出了一个全面的全癌症分析，旨在阐明Naa10p在癌症中发生失调的复杂性。我们的研究结果表明，c-Myc可能是影响Naa10p表达的调节因子。此外，我们总结了近期对Naa10p如何参与癌细胞增殖和转移的复杂分子基础的理解提供了综合性的摘要。此外，我们深入探讨了Naa10p在调节癌症行为方面多样化角色的本质，可能归因于其与多种伴侣蛋白质的相互作用。通过对Naa10p功能的详尽探索，涵盖其乙酰化活性和非乙酰转移酶相关功能，本综述为癌症治疗领域中涉及这一关键蛋白质的靶向治疗策略提供了新的见解。版权所有 © 2023. Elsevier B.V. 发表。

Nα-acetyltransferase 10 protein (Naa10p) is known as the catalytic subunit of N-terminal acetyltransferases A (NatA) complex, associating with Naa15p to acetylate N-termini of the human proteome. Recent investigations have unveiled additional functions for Naa10p, encompassing lysine ε-acetylation and acetyltransferase-independent activities. Its pleiotropic roles have been implicated in diverse physiological and pathological contexts. Emerging evidence has implicated Naa10p in cancer progression, demonstrating dual attributes as an oncogene or a tumor suppressor contingent on the cancer type and acetyltransferase activity context. In this comprehensive review, we present a pan-cancer analysis aimed at elucidating the intricacies underlying Naa10p dysregulation in cancer. Our findings propose the potential involvement of c-Myc as a modulatory factor influencing Naa10p expression. Moreover, we provide a consolidated summary of recent advancements in understanding the intricate molecular underpinnings through which Naa10p contributes to cancer cell proliferation and metastasis. Furthermore, we delve into the multifaceted nature of Naa10p's roles in regulating cancer behaviors, potentially attributed to its interactions with a repertoire of partner proteins. Through an exhaustive exploration of Naa10p's functions, spanning its acetylation activity and acetyltransferase-independent functionalities, this review offers novel insights with implications for targeted therapeutic strategies involving this pivotal protein in the realm of cancer therapeutics.Copyright © 2023. Published by Elsevier B.V.