重症大细胞淋巴瘤的转化（RT）是指慢性淋巴细胞白血病（在成年人中最常见的白血病）进展为高度侵袭性淋巴增生性疾病，主要为弥漫性大B细胞淋巴瘤。这是一种严重的并发症，仍然是治疗挑战和未满足的医学需求。在过去五年中，已经取得了重大进展，揭示了导致RT的生物过程，优化了将RT与其他实体正确诊断的标准，并探索了超出无效化疗的新的治疗选择。本综述总结了RT领域的最新知识，包括RT发病机制的最新进展，RT分类的最新进展，以及对于这种严重并发症的新疗法的开发。版权所有 © 2023 Elsevier Ltd. 发表。

Richter transformation (RT) refers to the progression of chronic lymphocytic leukemia, the most prevalent leukemia among adults, into a highly aggressive lymphoproliferative disorder, primarily a diffuse large B-cell lymphoma. This is a severe complication that continues to be a therapeutic challenge and remains an unmet medical need. Over the last five years, significant advances have occurred in uncovering the biological processes leading to the RT, refining criteria for properly diagnose RT from other entities, and exploring new therapeutic options beyond the ineffective chemotherapy. This review summarizes current knowledge in RT, including recent advances in the understanding of the pathogenesis of RT, in the classification of RT, and in the development of novel therapeutic strategies for this grave complication.Copyright © 2023. Published by Elsevier Ltd.