乳腺癌是全球妇女中最常见的肿瘤。乳腺癌的诊断和治疗常伴随压力和抑郁。自我效能是癌症研究中最重要的个人特征之一，与抑郁和免疫力相关。本研究旨在以下方面进行： 1. 检查应对自我效能与抑郁、脱氢表雄酮（DHEA）水平和免疫力之间的相关性；2. 检查抑郁与DHEA水平之间的相关性；3. 研究抑郁和DHEA水平对免疫力的影响；4. 检查DHEA水平在应对自我效能与免疫力之间的相关性中的中介效应。方法：从开罗大学捐献者医院肿瘤科招募30名新诊断的乳腺癌患者（年龄为51.40±8.24岁），填写两份调查问卷：应对自我效能量表（CSES）和患者健康问卷-9（PHQ-9）；采集血样，通过流式细胞术和酶联免疫吸附测定法测量患者细胞免疫表型和DHEA水平。CSES与PHQ-9之间存在显著负相关，PHQ-9与B细胞计数之间存在显著正相关，CSES与B细胞计数之间存在显著负相关。DHEA的存在对CSES与B细胞计数之间的相关没有中介作用。本文提出了一种新的心理神经免疫学模型，通过提出应对自我效能对乳腺癌患者免疫力的影响。© 2023年。埃及国家癌症研究所。

Breast cancer is the most common tumor among women throughout the world. Diagnosis and treatment of breast cancer are associated with stress and depression. Self-efficacy is one of the most important personal characteristics, studied in cancer, and is correlated with depression and immunity. The aim of the study is as follows: 1. Examining the correlation between coping self-efficacy with depression, DHEA levels, and immunity 2. Examining the correlation between depression and DHEA levels 3. Studying the effect of depression and DHEA levels on immunity 4. Examining the intermediate effect of DHEA levels on the correlation between coping self-efficacy and immunity METHODS: Thirty newly diagnosed breast cancer patients recruited from the Oncology Department, Kasr EL-Aini, Cairo University (ages 51.40 + 8.24 years) responded to two questionnaires: Coping Self-Efficacy Scale (CSES) and Patient Health Questionnaire-9 (PHQ-9); blood samples were collected to measure the phenotype of patients' cellular immunity and DHEA levels by flowcytometry and ELISA technique.There was a significant negative correlation between CSES and PHQ-9, a significant positive correlation between PHQ-9 and B-cell count, and there is a significant negative correlation between CSES and B-cell count. The presence of DHEA has no mediatory role on correlation between CSES and B-cell count.This paper presents a new model of psychoneuroimmunology by suggesting an effect of coping self-efficacy on immunity against breast cancer patients.© 2023. Egyptian National Cancer Institute.