尽管近年来进行了大量研究，但目前治疗神经系统疾病的方法仍不理想。姜黄素是一种存在于姜黄属植物中的多酚，已经证明其可以缓解神经炎症和神经退行性疾病的病理生理过程和临床后遗症。我们在PubMed数据库中搜索与姜黄素及其在治疗神经系统疾病中的应用相关的出版物。我们还通过在PubMed数据库中使用“姜黄素和临床试验”进行搜索，回顾了相关的临床试验。本综述详细阐述了姜黄素、其衍生物和制剂在各种临床前和临床研究中的多种免疫调节和神经保护作用。对姜黄素对神经退行性疾病如阿尔茨海默病（AD）、肌萎缩性侧索硬化症（ALS）、脑肿瘤、癫痫、亨廷顿病（HD）、缺血、帕金森病（PD）、多发性硬化症（MS）和颅脑损伤（TBI）的影响以及相关信号通路进行了全面讨论。本综述证明姜黄素可以通过调节多种星形胶质细胞介导的级联反应来抑制脊髓神经炎症，确保神经系统疾病的治疗。©2023年韩国东方医学研究所。由Elsevier B.V.出版。

Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases.We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using 'Curcumin and clinical trials'.This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed.This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of neurological disorders.© 2023 Korea Institute of Oriental Medicine. Published by Elsevier B.V.